{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:24:00Z","timestamp":1759134240323,"version":"3.37.3"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p\/>\n                  <jats:p>The aim of this study was to evaluate the 18-year results of emergency operations for acute type A aortic dissection, especially in octogenarians.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We reviewed 199 patients who underwent surgical aortic repair of an acute type A aortic dissection from January 2001 to December 2018. If the primary entry existed in the ascending aorta, we limited the extent of the replacement to within the ascending aorta. We analysed the early and late outcomes and identified the predictive factors for in-hospital death and difficulty of direct discharge to home.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The hospital mortality was 16%. The causes of death were postoperative bleeding (n\u2009=\u20098, 4%), intestinal ischaemia (n\u2009=\u20096, 3%), respiratory failure (n\u2009=\u20095, 3%), systemic inflammatory response syndrome (n\u2009=\u20094, 2%), low output syndrome (n\u2009=\u20093, 2%), sudden death (n\u2009=\u20093, 2%), myonephrotic metabolic syndrome (n\u2009=\u20092, 1%) and stroke (n\u2009=\u20091, 1%). Multivariable analysis revealed that an estimated glomerular filtration rate &amp;lt;30 (P\u2009=\u20090.006), malperfusion (P\u2009=\u20090.001), rupture (P\u2009&amp;lt;\u20090.001) and cross-clamping time (P\u2009=\u20090.003) were independent predictive factors of in-hospital death. Age was not a significant factor for predicting in-hospital death. Ascending aorta replacement (P\u2009=\u20090.013), advanced age (P\u2009=\u20090.002) and prolonged extracorporeal circulation time (P\u2009=\u20090.009) were independent predictive factors of difficulty in direct discharge to home. In the late follow-up period, the 5-year survival and aortic event-free rates were 62.2% and 88.9% in octogenarians, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>From the perspective of saving lives, the results of emergency surgery for octogenarians were acceptable. Avoiding the postoperative decline in activities of daily living in octogenarians is a consideration going forward.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaa195","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T11:07:07Z","timestamp":1589195227000},"page":"949-956","source":"Crossref","is-referenced-by-count":11,"title":["The results of an entry-oriented strategy for acute type A aortic dissection in octogenarians: an 18-year experience"],"prefix":"10.1093","volume":"58","author":[{"given":"Takashi","family":"Igarashi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirono","family":"Satokawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Takase","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Wakamatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Seto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0698-4560","authenticated-orcid":false,"given":"Masumi","family":"Iwai-Takano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1079-5324","authenticated-orcid":false,"given":"Tsuyoshi","family":"Fujimiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroharu","family":"Shinjo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"2020102110253717100_ezaa195-B1","first-page":"517","article-title":"A preoperative index of mortality for patients undergoing surgery of type A aortic dissection","volume":"42","author":"Spirito","year":"2001","journal-title":"J Cardiovasc Surg"},{"key":"2020102110253717100_ezaa195-B2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.athoracsur.2009.04.096","article-title":"Outcomes after surgical treatment for type A acute aortic dissection in octogenarians: a multicenter study","volume":"88","author":"Piccardo","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"2020102110253717100_ezaa195-B3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jtcvs.2016.03.093","article-title":"Outcomes of limited proximal aortic replacement for type A aortic dissection in octogenarians","volume":"152","author":"Kondoh","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020102110253717100_ezaa195-B4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.athoracsur.2017.06.057","article-title":"Early and late surgical outcomes of acute type A aortic dissection in octogenarians","volume":"105","author":"Kawahito","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"2020102110253717100_ezaa195-B5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.je.2016.09.008","article-title":"Prevalence of frailty in Japan: a systematic review and meta-analysis","volume":"27","author":"Kojima","year":"2017","journal-title":"J Epidemiol"},{"key":"2020102110253717100_ezaa195-B6","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.athoracsur.2014.01.045","article-title":"Surgical outcomes of acute type A aortic dissection in elderly 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