{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:50:19Z","timestamp":1767340219613},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Key R&D Program of China","award":["2017YFC1308100"],"award-info":[{"award-number":["2017YFC1308100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2002<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The optimal timing for atrioventricular valve (AVV) repair in patients with a Fontan circulation remains controversial. Few studies have reported the long-term outcomes of AVV repair concomitant with a Fontan operation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>From January 2006 to December 2018, a total of 89 patients who developed moderate or severe AVV regurgitation before a Fontan operation were divided into 2 groups: group 1, including 37 patients who did not undergo concomitant AVV repair; and group 2, including 52 patients who received AVV repair concomitant with a Fontan operation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The mean age at the time of the Fontan operation was 6.74\u2009years for group 1 and 8.96\u2009years for group 2, respectively. Early death occurred in 3 patients [2 patients (5.4%) in group 2, patient 1 (1.9%) in group 1]. Freedom from long-term death, cardiac function reduction and protein-losing enteropathy were similar among the 2 groups. Common AVV function was apparently poorer than mitral valve function after repair [hazard ratio (HR) 3.83, 95% confidence interval (CI) 1.31\u201311.17; P\u2009=\u20090.014]. The occurrence of AVV valve failure in group 1 was lower than that in group 2 (HR 0.44, 95% CI 0.22\u20130.91; P\u2009=\u20090.026). AVV function became worse during the follow-up period than that at discharge in both groups (P\u2009=\u20090.03 in group 1 and P\u2009=\u20090.001 in group 2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The long-term results of AVV repair concomitant with a Fontan operation are favourable.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaa464","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T20:59:39Z","timestamp":1607461179000},"page":"832-838","source":"Crossref","is-referenced-by-count":3,"title":["Long-term results of concomitant atrioventricular valve intervention and the Fontan operation"],"prefix":"10.1093","volume":"59","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"Pediatric Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zicong","family":"Feng","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Ma","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Qi","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoujun","family":"Li","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"2021042915240609800_ezaa464-B1","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.jtcvs.2019.08.129","article-title":"Management of the bad atrioventricular valve in Fontan\u2026time for a change","volume":"158","author":"Stephens","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021042915240609800_ezaa464-B2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0022-5223(97)70322-2","article-title":"Modified Fontan procedure in ninety-nine cases of atrioventricular valve regurgitation","volume":"113","author":"Imai","year":"1997","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021042915240609800_ezaa464-B3","first-page":"3","article-title":"Atrioventricular valve regurgitation in patients with single ventricle: impact of the bidirectional cavopulmonary anastomosis","volume":"4975","author":"Mahle","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"2021042915240609800_ezaa464-B4","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.athoracsur.2010.06.086","article-title":"Early surgical correction of atrioventricular valvular regurgitation in single-ventricle patients","volume":"90","author":"Kwak","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"2021042915240609800_ezaa464-B5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/ejcts\/ezw091","article-title":"Clinical outcome following total cavopulmonary connection","volume":"50","author":"Ono","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021042915240609800_ezaa464-B6","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1253\/circj.CJ-15-1371","article-title":"Outcome of tricuspid valve plasty in norwood stage I operation","volume":"80","author":"Huang","year":"2016","journal-title":"Circ J"},{"key":"2021042915240609800_ezaa464-B7","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.athoracsur.2015.01.035","article-title":"Outcomes of atrioventricular valve operation in patients with fontan circulation","volume":"99","author":"Liu","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"2021042915240609800_ezaa464-B8","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/ejcts\/ezx025","article-title":"Common atrioventricular valve failure during single ventricle palliation","volume":"51","author":"King","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021042915240609800_ezaa464-B9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.athoracsur.2012.03.058","article-title":"Long-term outcomes after atrioventricular valve operations in patients undergoing single-ventricle palliation","volume":"94","author":"Wong","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"2021042915240609800_ezaa464-B10","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jacc.2018.12.025","article-title":"Atrioventricular valve failure in Fontan palliation","volume":"73","author":"King","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2021042915240609800_ezaa464-B11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jtcvs.2017.08.122","article-title":"Atrioventricular valve regurgitation in patients undergoing total cavopulmonary connection: Impact of valve morphology and underlying mechanisms on survival and reintervention","volume":"155","author":"Ono","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021042915240609800_ezaa464-B12","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jtcvs.2016.04.040","article-title":"Outcomes of neonates requiring prolonged stay in the intensive care unit after surgical repair of congenital heart disease","volume":"152","author":"Mori","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021042915240609800_ezaa464-B13","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.athoracsur.2011.05.055","article-title":"Impact of the evolution of the Fontan operation on early and late mortality: a single-center experience of 405 patients over 3 decades","volume":"92","author":"Ohuchi","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"2021042915240609800_ezaa464-B14","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/ejcts\/ezu489","article-title":"Results of Fontan operation in patients with atrioventricular valve regurgitation","volume":"48","author":"Podzolkov","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021042915240609800_ezaa464-B15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1053\/j.pcsu.2011.02.001","article-title":"Atrioventricular valve repair in patients with single-ventricle physiology: mechanisms, techniques of repair, and clinical outcomes","volume":"14","author":"Honjo","year":"2011","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"2021042915240609800_ezaa464-B16","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jacc.2018.12.026","article-title":"Bad atrioventricular valve, bad Fontan: stop creating bad Fontans","volume":"73","author":"Cetta","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2021042915240609800_ezaa464-B17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1017\/S1047951110001538","article-title":"Long-term outcome after atrioventricular valve surgery following modified Fontan operation","volume":"21","author":"Menon","year":"2011","journal-title":"Cardiol Young"},{"key":"2021042915240609800_ezaa464-B18","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.jtcvs.2017.06.042","article-title":"Successful atrioventricular valve repair improves long-term outcomes in children with unbalanced atrioventricular septal defect","volume":"154","author":"Buratto","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021042915240609800_ezaa464-B19","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/icvts\/ivy155","article-title":"Mid-term result of atrioventricular valve replacement in patients with a single ventricle","volume":"27","author":"Sughimoto","year":"2018","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2021042915240609800_ezaa464-B20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1253\/circj.CJ-18-0916","article-title":"Outcomes of common atrioventricular valve repair in patients with single-ventricle physiology: indication, timing and repair techniques","volume":"83","author":"He","year":"2019","journal-title":"Circ J"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ejcts\/article-pdf\/59\/4\/832\/37581466\/ezaa464.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ejcts\/article-pdf\/59\/4\/832\/37581466\/ezaa464.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T15:24:48Z","timestamp":1619709888000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/59\/4\/832\/6128450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,4]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2,4]]},"published-print":{"date-parts":[[2021,4,29]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezaa464","relation":{},"ISSN":["1010-7940","1873-734X"],"issn-type":[{"value":"1010-7940","type":"print"},{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2021,2,4]]}}}