{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T22:56:09Z","timestamp":1772319369129,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Functional mitral regurgitation (FMR) is a sequel of left ventricular (LV) remodelling in heart failure patients. Relocation of both papillary muscles aims to specifically address mitral leaflet tethering to improve long-term durability of modern FMR repair. Nevertheless, the prognostic impact of the underlying cardiomyopathy on the outcome after FMR repair is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We analysed 84 consecutive heart failure patients with severe FMR, LV ejection fraction &amp;lt;40%, LV end-diastolic diameter \u226555\u2009mm and tenting height &amp;gt;10\u2009mm, who underwent ring annuloplasty and simultaneous bilateral papillary muscles relocation between June 2016 and March 2019. One-year outcome of 54 patients with ischaemic cardiomyopathy (\u2018ICM group\u2019) was prospectively compared to the remaining 30 patients with dilated cardiomyopathy (\u2018DCM group\u2019).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>One-year survival was similar in both groups (96% in the \u2018ICM group\u2019 vs 97% in the \u2018DCM group\u2019; P\u2009=\u20090.93). Furthermore, primary composite outcome (i.e. freedom from death or mitral regurgitation\u2009\u2265\u20092) at 1-year postoperatively was comparable between the study groups (94%in the \u2018ICM group\u2019 vs 87% in the \u2018DCM group\u2019; P\u2009=\u20090.10). LV end-diastolic diameter 1-year after surgery was significantly reduced, as compared to preoperative values, in the \u2018DCM group\u2019 (P\u2009=\u20090.018), but not in the \u2018ICM group\u2019 (P\u2009=\u20090.058). Improvement of New York Heart Association functional class and reduction of serum levels of N-terminal pro-B natriuretic peptide at 1 year was comparable in both study groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Standardized relocation of both papillary muscles to correct FMR resulted in very satisfactory in-hospital and 1-year outcomes, in both ICM and DCM. DCM patients showed similar improvement in heart failure symptoms and LV re-remodelling compared to ICM patients. Subannular repair is developing towards a valid therapeutic option in heart failure patients presenting with severe FMR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab048","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T04:35:06Z","timestamp":1611290106000},"page":"122-130","source":"Crossref","is-referenced-by-count":15,"title":["Subannular repair for functional mitral regurgitation type IIIb in patients with ischaemic versus dilated cardiomyopathy"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7418-1815","authenticated-orcid":false,"given":"Jonas","family":"Pausch","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Sequeira Gross","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"von Stumm","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Kloth","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Reichenspurner","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evaldas","family":"Girdauskas","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center Hamburg, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"2021071410033058400_ezab048-B1","doi-asserted-by":"crossref","first-page":"i17","DOI":"10.1093\/ejcts\/ezy344","article-title":"Minimally invasive mitral valve repair for functional mitral regurgitation","volume":"55","author":"Girdauskas","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021071410033058400_ezab048-B2","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/hrt.2005.067421","article-title":"Surgical reconstruction of the mitral valve","volume":"92","author":"Tuladhar","year":"2006","journal-title":"Heart"},{"key":"2021071410033058400_ezab048-B3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jchf.2017.06.015","article-title":"Evolution of functional mitral regurgitation and prognosis in medically managed heart failure patients with reduced ejection fraction","volume":"5","author":"Nasser","year":"2017","journal-title":"JACC Heart Fail"},{"key":"2021071410033058400_ezab048-B4","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1136\/hrt.2011.225789","article-title":"Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy","volume":"97","author":"Rossi","year":"2011","journal-title":"Heart"},{"key":"2021071410033058400_ezab048-B5","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ejhf.1491","article-title":"Treatment of functional mitral regurgitation in chronic heart failure: can we get a \u2018proof of concept\u2019 from the MITRA-FR and COAPT trials?","volume":"21","author":"Senni","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2021071410033058400_ezab048-B6","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"2021071410033058400_ezab048-B7","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in 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