{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:36:56Z","timestamp":1781851016573,"version":"3.54.5"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (KAKENHI","award":["JP19K09252"],"award-info":[{"award-number":["JP19K09252"]}]},{"name":"Subsidy Program for the Development of International Standards for the Evaluation of Innovative Medical Devices and Regenerative Medicine Products, of the Ministry of Health, Labour and Welfare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2002<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Sinus plication has emerged as a promising tool that can lead to better stability in bicuspid aortic valve (BAV) repair. However, the mechanisms underlying the efficacy of this technique are unclear. We evaluated the hydrodynamic effect of sinus plication using the experimental pulsatile flow simulator and our original BAV model in vitro.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Based on the computed tomography data of a BAV patient who had undergone aortic valvuloplasty, a BAV model (group C, n\u2009=\u20096) was developed with bovine pericardium and vascular prosthesis (J-graft Shield Neo Valsalva 24\u2009mm). We performed sinus plication (group SP, n\u2009=\u20096) in the BAV model and compared hydrodynamic data with the control model in the pulsatile flow simulator. Non-fused cusp angle, annulus diameter and effective height were measured by ultrasonography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The average flow was significantly increased in group SP compared to group C (4.24\u2009\u00b1\u20090.14\u2009l\/min vs 4.14\u2009\u00b1\u20090.15\u2009l\/min, respectively, P\u2009=\u20090.034). The mean transvalvular pressure gradient and regurgitant fraction were significantly decreased in group SP compared to group C (11.6\u2009\u00b1\u20094.3\u2009mmHg vs 16.6\u2009\u00b1\u20095.0\u2009mmHg, respectively, P\u2009=\u20090.009 and 14.1\u2009\u00b1\u20092.0% vs 17.4\u2009\u00b1\u20092.1%, respectively, P\u2009=\u20090.001). Ultrasound measurement indicated that non-fused cusp angle was significantly increased in group SP compared to group C (163.8\u00b0 \u00b1 9.2\u00b0 vs 153.0\u00b0 \u00b1 4.6\u00b0, respectively, P\u2009=\u20090.012).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Sinus plication in the BAV model significantly increased the commissural angle. It was effective in not only controlling regurgitation but also improving valve opening. These finding should be confirmed by evaluating cusp stress and\/or long-term durability in the future studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab115","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T15:13:14Z","timestamp":1613142794000},"page":"859-864","source":"Crossref","is-referenced-by-count":8,"title":["The efficacy of sinus plication in aortic valvuloplasty for bicuspid aortic valve: experiments in a pulsatile flow simulation model"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-5632","authenticated-orcid":false,"given":"Satoshi","family":"Arimura","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumpei","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gohki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Nakama","sequence":"additional","affiliation":[{"name":"Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eita","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Matsuhama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Cardiovascular Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-5509","authenticated-orcid":false,"given":"Kiyotaka","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan"},{"name":"Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kasegawa","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-6501","authenticated-orcid":false,"given":"Takashi","family":"Kunihara","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"2021102217440840100_ezab115-B1","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1016\/j.jacc.2009.12.068","article-title":"Bicuspid aortic valve disease","volume":"55","author":"Siu","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2021102217440840100_ezab115-B2","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.107.740878","article-title":"Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the 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