{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T20:42:55Z","timestamp":1770583375674,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2002<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Our goal was to investigate whether the incidence of valve-related adverse events might be different depending on the valve substitute after valve replacement for left-sided native valve endocarditis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We assessed the long-term freedom from recurrence, reoperation and survival of 395 patients who had valve replacements for native valve endocarditis (314 mechanical vs 81 biological). Age &amp;lt;18\u2009years, reoperation, prosthetic endocarditis, right valve involvement, valve repair and homograft implants were the main exclusion criteria. The balance between the 2 groups was addressed by weighting the results on the inverse of the propensity score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>After inverse probability of treatment weighting (IPTW), freedom from recurrence of infective endocarditis was not significantly different (mechanical 84.1\u2009\u00b1\u20093.2% vs 50.6\u2009\u00b1\u200921.7%; P\u2009=\u20090.29) nor was freedom from reoperation different (mechanical 85.7\u2009\u00b1\u20093.1% vs biological 50.9\u2009\u00b1\u200921.9%; P\u2009=\u20090.29). Excluding competing deaths, patients receiving a bioprosthesis had a similar subdistribution hazard of the above end points compared to recipients of a mechanical valve [recurrence IPTW: hazard ratio (HR) 1.631, 95% confidence interval (CI) 0.756\u20133.516; P\u2009=\u20090.21; reoperation IPTW-HR 1.737, 95% CI 0.780\u20133.870; P\u2009=\u20090.18]. Mechanical valves were associated with improved long-term survival (34.9\u2009\u00b1\u20095.8% vs 10.5\u2009\u00b1\u20097.4% at 30\u2009years; P\u2009=\u20090.0009; in particular: aortic valve subgroup 41.6\u2009\u00b1\u20099.3% vs 10.1\u2009\u00b1\u20098.2%; P\u2009&amp;lt;\u20090.0001), although the hazard of cardiovascular mortality did not favour either valve type (IPTW: HR 1.361, 95% CI 0.771\u20132.404; P\u2009=\u20090.29).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our analysis showed a clinical trend in favour of mechanical valves as valve substitutes for native valve endocarditis, especially in the aortic position. In view of long-term freedom from adverse events, the choice of the valve type should be tailored according to patient characteristics and specific clinical conditions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab238","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T19:15:40Z","timestamp":1619205340000},"page":"1388-1394","source":"Crossref","is-referenced-by-count":5,"title":["Can prosthesis type influence the recurrence of infective endocarditis after surgery for native valve endocarditis? A propensity weighted comparison"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-7422","authenticated-orcid":false,"given":"Antonino S","family":"Rubino","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"},{"name":"Cardiac Surgery Unit, Cardio-Thoraco-Vascular Department, Papardo Hospital, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester E","family":"Della Ratta","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Galbiati","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasul","family":"Ashurov","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana L","family":"Galgano","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2735-3036","authenticated-orcid":false,"given":"Antonio P","family":"Montella","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa","family":"De Feo","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-3339","authenticated-orcid":false,"given":"Alessandro","family":"Della Corte","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"2021120506080365400_ezab238-B1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/jama.2018.7596","article-title":"Management considerations in infective endocarditis: a 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