{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:09:41Z","timestamp":1783667381329,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["81772006"],"award-info":[{"award-number":["81772006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Our goal was to investigate the correlation of clinical and computed tomography (CT) features of thymic epithelial tumours (TET) with the World Health Organization classification and the Masaoka\u2013Koga staging system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Clinical and CT imaging data from 159 patients surgically and pathologically diagnosed with TET (82 men, 77 women; mean [\u00b1 standard deviation] age, 52.08\u2009\u00b1\u200911.76\u2009years) were retrospectively collected and reviewed. CT features were evaluated by radiologists. Tumour size, morphology, margin, density, calcification, cystic necrosis, density of the fat layer around the tumour, invasion of surrounding tissues, mediastinal lymph node enlargement, pleural\/pericardial effusion, metastasis, plain CT scans and enhanced CT values were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of the 159 patients with TET, 76 had low-risk thymoma, 55 had high-risk thymoma and 28 had thymic carcinomas. Age, maximum tumour diameter, myasthenia gravis, morphology, edges, density, fat around the lesion, mediastinal vascular, pericardial and lung tissue invasion, pleural\/pericardial effusion, metastasis and arterial phase CT values were statistically different among the 3 groups (P\u2009&amp;lt;\u20090.05). Multivariate regression analysis revealed that edges, fat around the lesion, mediastinal vascular invasion and pericardial effusion were most relevant to TET classification. The 159 patients with TET were categorized into the non-invasion group (stage I; n\u2009=\u200958); the invasion of surrounding fat (stage II; n\u2009=\u200946); and the invasion of surrounding structures and metastasis group (stages III and IV; n\u2009=\u200955). Tumour diameter, morphology, margins, density, cystic degeneration and necrosis, invasion of surrounding fat and structure, pleural and pericardial effusion and lymph node enlargement were statistically different among the 3 groups (P\u2009&amp;lt;\u20090.05). Multivariate regression analysis revealed that edges, fat around the lesion, mediastinal vascular invasion and pleura invasion were the most relevant CT signs in relation to TET staging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Analysis of clinical and CT features before surgery may facilitate the preliminary classification and stage diagnosis of TET.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab349","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T19:11:32Z","timestamp":1625857892000},"page":"742-748","source":"Crossref","is-referenced-by-count":10,"title":["Correlation of clinical and computed tomography features of thymic epithelial tumours with World Health Organization classification and Masaoka\u2013Koga staging"],"prefix":"10.1093","volume":"61","author":[{"given":"Qing","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology, Lanzhou University Second Hospital, Gansu, China"},{"name":"Second Clinical School, Lanzhou University, Gansu, China"},{"name":"Key Laboratory of Medical Imaging of Gansu Province, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lanzhou University Second Hospital, Gansu, China"},{"name":"Second Clinical School, Lanzhou University, Gansu, China"},{"name":"Key Laboratory of Medical Imaging of Gansu Province, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiqiang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lanzhou University Second Hospital, Gansu, China"},{"name":"Second Clinical School, Lanzhou University, Gansu, China"},{"name":"Key Laboratory of Medical Imaging of Gansu Province, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-6347","authenticated-orcid":false,"given":"Junlin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lanzhou University Second Hospital, Gansu, China"},{"name":"Key Laboratory of Medical Imaging of Gansu Province, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"2022032512421907500_ezab349-B1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00005382-198801000-00010","article-title":"Computed tomography and pathologic correlations of thymic lesions","volume":"3","author":"Chen","year":"1988","journal-title":"J Thorac 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