{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:09:54Z","timestamp":1762376994658,"version":"3.41.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>This is a comprehensive analysis of haemodynamics after valve-sparing aortic root replacement (VSARR) with anatomically curved prosthesis (CP) compared to straight prosthesis (SP) and age-matched volunteers (VOL) using 4D flow MRI (time-resolved three-dimensional magnetic resonance phase-contrast imaging).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Nine patients with 90\u00b0 CP, nine patients with SP, and twelve VOL were examined with 4D flow MRI. Analyses included various characteristic anatomical, qualitative and quantitative haemodynamic parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Grading of secondary flow patterns was lower in CP patients than in SP patients (P\u2009=\u20090.09) and more comparable to VOL, albeit not reaching statistical significance. However, it was easy to differentiate between VSARR patients and healthy volunteers: Patients more often had angular aortic arches (CP: 89%, SP: 100%; VOL: 17%; P\u2009\u2264\u20090.002), increased average curvature (CP: 0.17\/cm [0.15, 0.18]; SP: 0.15\/cm [0.14, 0.16]; VOL: 0.14\/cm [0.13, 0.16]; P\u2009\u2264\u20090.007; values given as median [interquartile range]), and more secondary flow patterns (CP: 3 [2, 4] SP: 3 [2, 3] VOL: 2 [1, 2]; P\u2009&amp;lt;\u20090.01). Maximum circulation (CP: 142.7 cm2\/s [116.1, 187.3]; SP: 101.8 cm2\/s [77.7, 132.5]; VOL: 42.8cm2\/s [39.3, 65.6]; P\u2009\u2264\u20090.002), maximum helicity density (CP: 9.6\u2009m\/s2 [9.3, 23.9]; SP: 9.7\u2009m\/s2 [8.6, 12.5]; VOL 4.9\u2009m\/s2 [4.2, 7.7]; P\u2009\u2264\u20090.007), and wall shear stress gradient (e.g., proximal ascending aorta CP: 0.97\u2009N\/m2 [0.54, 1.07]; SP: 1.08\u2009N\/m2 [0.74, 1.24]; VOL: 0.41\u2009N\/m2 [0.32, 0.60]; P\u2009\u2264\u20090.01) were increased in patients. One CP patient had a round aortic arch with physiological haemodynamic parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The restoration of physiological aortic configuration and haemodynamics was not fully achieved with the curved prostheses in our study cohort. However, there was a tendency towards improved haemodynamic conditions in the patients with curved prostheses overall but without statistical significance. A single patient with a CP and near-physiological configuration of the thoracic aorta underlines the importance of optimizing postoperative geometric conditions for allowing for physiological haemodynamics and cardiovascular energetics after VSARR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab352","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T11:12:46Z","timestamp":1626174766000},"source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive analysis of haemodynamics in patients with physiologically curved prostheses of the ascending aorta"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-2892","authenticated-orcid":false,"given":"Malte Maria","family":"Sieren","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Universit\u00e4t zu L\u00fcbeck , L\u00fcbeck, 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Huellebrand","sequence":"additional","affiliation":[{"name":"Fraunhofer MEVIS , Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9331-6703","authenticated-orcid":false,"given":"Michael","family":"Scharfschwerdt","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Thoracic Vascular Surgery, Universit\u00e4t zu L\u00fcbeck , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8937-1198","authenticated-orcid":false,"given":"J\u00f6rg","family":"Barkhausen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Universit\u00e4t zu L\u00fcbeck , L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-5565","authenticated-orcid":false,"given":"Alex","family":"Frydrychowicz","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Universit\u00e4t zu L\u00fcbeck , L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-6345","authenticated-orcid":false,"given":"Dominik Daniel","family":"Gabbert","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein , Campus Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1931-1912","authenticated-orcid":false,"given":"Thekla Helene","family":"Oechtering","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Universit\u00e4t zu L\u00fcbeck , 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