{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:06:15Z","timestamp":1793113575072,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2002<\/jats:title>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Updated European guidelines recommend annual echocardiographic evaluation after bioprosthetic surgical aortic valve replacement (bio-SAVR). Given the increased demand on health care resources, only clinically relevant controls can be prioritized. We therefore aimed to explore reintervention rates following bio-SAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>From the nationwide Danish Register of Surgical Procedures, we identified all patients \u226540\u2009years with isolated bio-SAVR \u00b1 concomitant coronary artery bypass graft surgery (CABG) during 2000\u20132016. In 90-day reintervention-free survivors, we assessed aortic valve reintervention rates (primary outcome) and all-cause mortality rates (secondary outcome) at 1, 3 and 5 years with total follow-up until 31 December 2017 and further estimated annual theoretical echocardiographic control visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In 10\u2009518 patients with bio-SAVR (+CABG 39.7%), we observed low reintervention rates at 1, 3 and 5 years, but with high rates of all-cause mortality; i.e. 5-year reintervention rate of 3.7\/1000 person-years (\u22641.5%) and 5-year mortality rate of 21.7\/1000 person-years. Accounting for the competing risk of death, 5-year rates were inversely related to age group and remained relatively low across all age categories but increased gradually in the long term. A significant proportion of reinterventions were presumed due to infectious endocarditis (48% at 3\u2009years, 37% at 5\u2009years). With annual transthoracic echocardiography, the theoretical ratio of echocardiographies per reintervention in the first 5 years was 248, and 425 when endocarditis events were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Reintervention rates within the first 5 years following bio-SAVR were relatively rare, and with a substantial number due to endocarditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab365","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T23:13:34Z","timestamp":1627341214000},"page":"614-622","source":"Crossref","is-referenced-by-count":8,"title":["Reintervention rates following bioprosthetic surgical aortic valve replacement\u2014a Danish Nationwide Cohort Study"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1106-9316","authenticated-orcid":false,"given":"Michelle D S","family":"Schmiegelow","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Holb\u00e6k Sygehus, Holb\u00e6k, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3797-0735","authenticated-orcid":false,"given":"Hanne","family":"Elming","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-7971","authenticated-orcid":false,"given":"Kirstine L","family":"Sibilitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5026-9193","authenticated-orcid":false,"given":"Niels E","family":"Bruun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital, Roskilde, Denmark"},{"name":"Clinical Institute, Copenhagen University, Copenhagen, Denmark"},{"name":"Clinical Institute, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1367-6766","authenticated-orcid":false,"given":"Christian L","family":"Carranza","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8345-204X","authenticated-orcid":false,"given":"Jordi S","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-6131","authenticated-orcid":false,"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Department of Cardiology and Clinical Research, Nordsjaellands Hospital, Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren S","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"2022022016302560700_ezab365-B1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/ije\/dyr061","article-title":"Trends in European life expectancy: a salutary view","volume":"40","author":"Leon","year":"2011","journal-title":"Int J Epidemiol"},{"key":"2022022016302560700_ezab365-B2","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart 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