{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:30:37Z","timestamp":1770136237887,"version":"3.49.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2002<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Persistent lymph nodes infiltration after neoadjuvant treatment remains a controversial topic in the treatment of stage III non-small-cell lung cancer (NSCLC). The aim of this study is to identify subgroups with persistent N2 disease, who could experience survival benefit from the addition of surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A retrospective mono-institutional study was conducted to analyse all patients with a final histopathology of NSCLC and persistent mediastinal disease after induction chemotherapy or chemoradiotherapy and surgery from January 1998 to June 2015.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 145 patients (93 men, 52 women) fulfilled the inclusion criteria. The median age was 60\u2009years (range 38\u201378). A total of 82 (56.5%) patients received a lobectomy, 48 (33.1%) a pneumonectomy, 11 (7.6%) a bilobectomy and 4 (2.6%) an anatomical segmentectomy; 128 (88.3%) were completely resected (R0). Operative mortality was 2.6% (4 patients), and morbidity was 35.2% (51 patients). Overall survival at 5\u2009years was 47.3% (n\u2009=\u200919) for single N2 (skip), 30.2% (n\u2009=\u200916) for single N2 and N1 lymph nodes and under 5% (n\u2009=\u20091) for multiple mediastinal stations disease. Overall survival at 5\u2009years after lobectomy\/bilobectomy was not statistically different than after pneumonectomy (33.5% vs 20.5%, P\u2009=\u20090.082). Disease-free survival at 5\u2009years was 30.6% (n\u2009=\u20096) for ypN2a1, 23.4% (n\u2009=\u20097) for ypN2a2 and under 5% (n\u2009=\u20091) for ypN2b status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Lobectomy or bilobectomy has to be taken into account as a potentially curative option with promising long-term results for patients after induction treatment and persistent single-station N2 involvement (skip or additionally N1 status).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registry number<\/jats:title>\n                  <jats:p>14-6138-BO.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab372","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T11:08:50Z","timestamp":1628161730000},"page":"269-276","source":"Crossref","is-referenced-by-count":14,"title":["Significantly favourable outcome for patients with non-small-cell lung cancer stage IIIA\/IIIB and single-station persistent N2 (skip or additionally N1) disease after multimodality treatment"],"prefix":"10.1093","volume":"61","author":[{"given":"Georgios","family":"Stamatis","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery and Endoscopy, University Medicine Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Endoscopy, University Medicine Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, 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