{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:50:21Z","timestamp":1791723021479,"version":"4.3.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T00:00:00Z","timestamp":1628985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Medical and Health Technology Innovation Project of Chinese Academy of Medical Sciences","award":["018-12M-3-003"],"award-info":[{"award-number":["018-12M-3-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\u2002<\/jats:title>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>This prospective observational study aimed to investigate postoperative skeletal muscle and fat mass wasting and their clinical significance in oesophageal cancer patients undergoing minimally invasive McKeown oesophagectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Bioelectrical impedance analyses of body compositions were conducted before surgery and 1, 4 and 12\u2009weeks after surgery. Curve-fitting analysis was used to describe the relationship between changes in the skeletal muscle mass index (\u0394SMI) and fat mass index (\u0394FMI). A logistic regression-based nomogram was established using the R tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among the 78 patients, 74.4% were male, and the mean age was 64.8 [standard deviation (SD): 6.6] years. Decreased SMIs and FMIs were concentrated in the first 4 weeks after surgery, with proportions of \u22123.42% (SD: 4.58) and \u221217.7% (SD: 11.9), respectively. A negative relationship between \u0394FMI and \u0394SMI was detected by linear regression (coefficient \u22120.341, P\u2009&amp;lt;\u20090.001). Based on the median \u0394SMI to \u0394FMI ratio (35.5%), 2 postoperative weight loss types were defined: SMI-dominated (SMDT) and FMI-dominated (FMDT) types. SMDT patients reported increased feeding-related problems, poorer functional status and more unhealthy symptoms than FMDT patients within 12\u2009weeks after surgery. SMDT patients also showed poorer 2-year overall survival (71.1% vs 87.3%, P\u2009=\u20090.021) and disease-free survival (60.5% vs 84.9%, P\u2009=\u20090.032) than FMDT patients. A nomogram based on baseline and perioperative parameters was established to quantify postoperative SMDT and FMDT tendencies with good accuracy (C-index: 0.897).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The negative relationship between \u0394FMI and \u0394SMI indicated differentiated metabolism post-oesophagectomy. SMDT was associated with adverse therapeutic outcomes and warranted aggressive interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical registration number<\/jats:title>\n                    <jats:p>The study protocol was registered at the Chinese Clinical Trial Registry with the registration number ChiCTR1800018511.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab377","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T15:11:38Z","timestamp":1627312298000},"page":"259-266","source":"Crossref","is-referenced-by-count":9,"title":["The negative association between skeletal muscle and fat mass wasting caused by oesophagectomy in patients with oesophageal squamous cell carcinoma"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7021-3939","authenticated-orcid":false,"given":"Peiyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Peking University People\u2019s Hospital, Beijing, China"},{"name":"Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiankai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, National Cancer Center\/Cancer Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianben","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-5548","authenticated-orcid":false,"given":"Yin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, National Cancer Center\/Cancer Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,15]]},"reference":[{"key":"2022012513095380100_ezab377-B1","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/jamaoncol.2019.2996","article-title":"Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 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