{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:56:03Z","timestamp":1787932563108,"version":"build-2784847793"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2002<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Although left ventricular outflow tract (LVOT) obstruction is a recognized risk after atrioventricular (AV) septal defect (AVSD) repair, quantitative assessments to define the substrate of the obstruction are lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Morphometric analyses were based on measurements from early 2-dimensional echocardiographic scans (within 3\u2009months postoperatively) for 117 patients (82 CAVVO\u2009=\u2009common AV valve; 35 SAVVO\u2009=\u2009separate AV valve orifices), which were compared to 50 age\/weight matched controls (atrial septal defect\/ventricular septal defect). Late echocardiographic analyses were performed in 57 patients with AVSD (follow-up range, 1.2\u201310.7\u2009years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Adequate z scores (above \u22122.5) were observed in 109 (93%) patients with AVSD at the aortic annulus and in 89 (76%) with AVSD in the subaortic area. Compared to the control group, patients with AVSD had lower median z scores at the aortic annulus (\u22120.64 vs 0.60; P\u2009&amp;lt;\u20090.001) and the subaortic areas (\u22121.48 vs 0.59; P\u2009&amp;lt;\u20090.001), disproportionate subaortic\/aortic annulus ratio &amp;lt;1.00 (67% vs 22%; P\u2009&amp;lt;\u20090.001), narrower annuloaortic-septal angle (94.0 vs 104.0; P\u2009&amp;lt;\u20090.001) and annuloaortic left AV valve angle (78.0 vs 90.0; P\u2009&amp;lt;\u20090.001). Compared to patients with CAVVO, those with SAVVO had narrower annuloaortic-septal angles (P\u2009=\u20090.022) that persisted at late analysis, with lower subaortic\/aortic annular ratios (P\u2009=\u20090.039). In patients with CAVVO, lower early postoperative subaortic z scores were found following modified single-patch repairs (median \u22122.12 vs \u22121.02 in two-patch repairs; P\u2009=\u20090.004). A total of 6\/117 (5%) patients (4 CAVVO, 5% and 2 SAVVO, 6%) required reoperations for LVOT obstruction (mean 6.9\u2009years postoperatively), with no difference in morphology or types of operations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Despite having adequate z scores, patients with AVSD demonstrated abnormal LVOT morphometrics early postoperatively. Besides intrinsic morphology, repair techniques may have an impact on postoperative LVOT morphometrics and requires further evaluation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab397","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T11:07:04Z","timestamp":1629112024000},"page":"545-552","source":"Crossref","is-referenced-by-count":4,"title":["The role of abnormal subaortic morphometry as a substrate for left ventricular outflow tract obstruction following atrioventricular septal defect repair"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4424-1394","authenticated-orcid":false,"given":"Ashwini Suresh","family":"Chandiramani","sequence":"first","affiliation":[{"name":"College of Medical, Veterinary and Life Sciences, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Bader","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiac Surgery, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Finlay","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology\/Echocardiography, Royal Hospital for Children, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Lilley","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology\/Echocardiography, Royal Hospital for Children, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiac Surgery, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Medical, Veterinary and Life Sciences, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK"},{"name":"Department of Paediatric Cardiac Surgery, Royal Hospital for Children Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"2022022016290607200_ezab397-B1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jtcvs.2015.05.011","article-title":"Long-term outcomes after surgical repair of complete atrioventricular septal defect","volume":"150","author":"Ginde","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022022016290607200_ezab397-B2","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.athoracsur.2010.06.008","article-title":"More than 30 years\u2019 experience 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