{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T23:51:55Z","timestamp":1774741915307,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Postoperative mediastinitis, a feared complication after cardiac surgery, is associated with high mortality, especially of critically ill patients. Candida species infections are rare and severe, with poorly known outcomes. We conducted a case\u2013control study to describe the characteristics, management and outcomes of patients with postoperative Candida mediastinitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This French, monocentre, retrospective study included all patients with postoperative Candida mediastinitis (January 2003\u2013February 2020) requiring intensive care unit admission. Candida mediastinitis patients (henceforth cases) were matched 1:1 with postoperative bacterial mediastinitis (henceforth control), based on 3 factors during mediastinitis management: age &amp;gt;40\u2009years, cardiac transplantation and invasive circulatory device used. The primary end point was the probability of survival within 1\u2009year after intensive care unit (ICU) admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Forty cases were matched to 40 controls. The global male\/female ratio was 2.1, with mean age at admission 47.9\u2009\u00b1\u200913.8\u2009years. Candida species were: 67.5% albicans, 17.5% glabrata, 15% parapsilosis, 5.0% tropicalis, 2.5% krusei and 2.5% lusitaniae. The median duration of mechanical ventilation was 23, 68.8% of patients received renal replacement therapy and 62.5% extracorporeal membrane oxygenation support. The probability of survival within the first year after ICU admission was 40\u2009\u00b1\u20095.5% and was significantly lower for cases than for controls (43\u2009\u00b1\u20098% vs 80\u2009\u00b1\u20096.3%, respectively; Log-rank test: P &amp;lt; 0.0001). The multivariable Cox proportional hazards model retained only renal replacement therapy [hazard ratio (HR) 3.7, 95% confidence interval (CI) 1.1\u201313.1; P = 0.04] and Candida mediastinitis (HR 2.4, 95% CI 1.1\u20135.6; P = 0.04) as independently associated with 1-year mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Candida mediastinitis is a serious event after cardiac surgery and independently associated with 1-year mortality. Further studies are needed to determine whether deaths are directly attributable to Candida mediastinitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab437","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T19:21:13Z","timestamp":1633029673000},"page":"523-530","source":"Crossref","is-referenced-by-count":11,"title":["Characteristics and outcomes of patients with postoperative <i>Candida<\/i> versus bacterial mediastinitis: a case-matched comparative study"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-5191","authenticated-orcid":false,"given":"Quentin","family":"Moyon","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"},{"name":"Service de M\u00e9decine Interne, Sorbonne Universit\u00e9, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Institut E3M, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Lebreton","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Cardiothoracique, Sorbonne Universit\u00e9, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Institut de Cardiologie, Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS_1166-ICAN, Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florent","family":"Huang","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Demondion","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Cardiothoracique, Sorbonne Universit\u00e9, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Institut de Cardiologie, Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS_1166-ICAN, Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrielle","family":"Desnos","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Chommeloux","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"H\u00e9kimian","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Br\u00e9chot","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ania","family":"Nieszkowska","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS_1166-ICAN, Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Leprince","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Cardiothoracique, Sorbonne Universit\u00e9, APHP, H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Institut de Cardiologie, Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS_1166-ICAN, Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Combes","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS_1166-ICAN, Institut de Cardiom\u00e9tabolisme et Nutrition (ICAN), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7424-2705","authenticated-orcid":false,"given":"Charles-Edouard","family":"Luyt","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, Sorbonne Universit\u00e9, Assistance Publique-H\u00f4pitaux de Paris (APHP), H\u00f4pital La Piti\u00e9\u2013Salp\u00eatri\u00e8re, Paris, France"},{"name":"Sorbonne 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