{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T10:55:13Z","timestamp":1753354513879,"version":"3.37.3"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>In patients with deep sternal wound infection (DSWI), primary closure of the sternal bone over high negative pressure Redon drains has shown to be a safe and feasible treatment method. Addition of local gentamicin could accelerate healing and improve clinical outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We conducted a randomized controlled trial to evaluate the effectiveness of local gentamicin in the treatment of DSWI. In the treatment group, collagenous carriers containing gentamicin were left between the sternal halves during sternal refixation. In the control group, no local antibiotics were used. Primary outcome was hospital stay. Secondary outcomes were mortality, reoperation, wound sterilization time, time till removal of all drains and duration of intravenous antibiotic treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Forty-one patients were included in the trial of which 20 were allocated to the treatment group. Baseline characteristics were similar in both groups. Drains could be removed after a median of 8.5\u2009days in the treatment group and 14.5\u2009days in the control group (P-value: 0.343). Intravenous antibiotics were administered for a median of 23.5\u2009days in the treatment group and 38.5\u2009days in the control group (P-value: 0.343). The median hospital stay was 27\u2009days in the treatment group and 28\u2009days in the control group (P-value: 0.873). Mortality rate was 10% in the treatment group and 9.5% in the control group (P-value: 0,959). No side effects were observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This randomized controlled trial showed that addition of local gentamicin in the treatment of DSWI did not result in shorter length of stay.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration number<\/jats:title>\n                  <jats:p>2014-001170-33.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab479","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T03:31:44Z","timestamp":1634700704000},"page":"1135-1141","source":"Crossref","is-referenced-by-count":2,"title":["Application of local gentamicin in the treatment of deep sternal wound infection: a randomized controlled trial"],"prefix":"10.1093","volume":"61","author":[{"given":"Roemer J","family":"Vos","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart P","family":"van Putte","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, Netherlands"},{"name":"Department of Cardiothoracic Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bas A J M","family":"de Mol","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke","family":"Hoogewerf","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-4088","authenticated-orcid":false,"given":"Tim J","family":"Mandigers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey T L","family":"Kloppenburg","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St. Antonius Hospital, Nieuwegein, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,28]]},"reference":[{"key":"2022050515422723000_ezab479-B1","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ejcts.2006.09.020","article-title":"Poststernotomy mediastinitis: a review of conventional surgical treatments, vacuum-assisted closure therapy and presentation of the Lund University Hospital mediastinitis algorithm","volume":"30","author":"Sj\u00f6gren","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022050515422723000_ezab479-B2","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/j.athoracsur.2004.12.048","article-title":"Clinical outcome after poststernotomy mediastinitis: vacuum-assisted closure versus conventional treatment","volume":"79","author":"Sj\u00f6gren","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"2022050515422723000_ezab479-B3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.athoracsur.2004.08.032","article-title":"Clinical outcome of patients with deep sternal wound infection managed by vacuum-assisted closure compared to conventional therapy with open packing: a retrospective analysis","volume":"79","author":"Fuchs","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"2022050515422723000_ezab479-B4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1067\/mtc.2003.74","article-title":"Vacuum-assisted closure as a treatment modality for infections after cardiac surgery","volume":"125","author":"Luckraz","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022050515422723000_ezab479-B5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/icvts\/ivr049","article-title":"Vacuum-assisted closure of post-sternotomy mediastinitis as compared to open packing","volume":"14","author":"Vos","year":"2012","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2022050515422723000_ezab479-B6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/ejcts\/ezw326","article-title":"European Association for Cardio-Thoracic Surgery expert consensus statement on the prevention and management of mediastinitis","volume":"51","author":"Abu-Omar","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022050515422723000_ezab479-B7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0022-5223(19)35336-X","article-title":"Mediastinal infection after cardiac operation. 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