{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:13:51Z","timestamp":1791670431944,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The influence of preoperative left ventricular size in outcomes following centrifugal-flow left ventricular assist device (LVAD) implantation has not been well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A cohort of 313 patients who received a centrifugal-flow LVAD at a single institution was analysed. Using a maximally selected log-rank statistic, we investigated whether a left ventricular end-diastolic dimension (LVEDD) cut-off point was associated with worse outcomes. The cohort was then divided in 2 groups based on the LVEDD cut-off point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>An LVEDD cut-off point of 59 mm was found to predict worse survival. Smaller LVEDD patients (\u226459 mm, N = 52) were older and more likely to have a history of coronary artery disease compared those with a larger LVEDD (&amp;gt;59 mm, N = 261). Smaller LVEDD patients had lower survival compared to larger LVEDD patients (71% vs 85% at 1 year and 58% vs 80% at 2 years, P = 0.003). The need for temporary right ventricular mechanical support was significantly higher in the smaller LVEDD cohort (11.5% vs 1.9%, P = 0.002). Pump flows at time of discharge were lower in the smaller LVEDD group (3.8 vs 4.2 l\/min, P = 0.005), who also had a higher incidence of late right ventricular failure (23% vs 12%, P = 0.02), higher rates of gastrointestinal bleeding (0.416 vs 0.256 events per patient-year, P = 0.025) and higher readmissions secondary to low flow alarms (0.429 vs 0.240 events per patient-year, P = 0.007). Multivariable analysis demonstrated that smaller LVEDD, older age, high BUN and high bilirubin levels were independent predictors of worse survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In patients receiving a centrifugal-flow LVAD, smaller preoperative LVEDD (\u226459 mm) was associated with lower survival and higher incidence of adverse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab480","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T04:37:52Z","timestamp":1634618272000},"source":"Crossref","is-referenced-by-count":20,"title":["The impact of left ventricular size on outcomes after centrifugal-flow left ventricular assist device implantation"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-7483","authenticated-orcid":false,"given":"Ezequiel","family":"Molina","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Medstar Washington Hospital Center , Washington, DC, USA"},{"name":"Georgetown University School of Medicine , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6170-7224","authenticated-orcid":false,"given":"Amiti","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medstar Washington Hospital Center , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Advanced Heart Failure Program, Medstar Washington Hospital Center , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Lam","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine , Washington, DC, USA"},{"name":"Department of Cardiology, Advanced Heart Failure Program, Medstar Washington Hospital Center , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-5108","authenticated-orcid":false,"given":"Sriram","family":"Rao","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine , Washington, DC, USA"},{"name":"Department of Cardiology, Advanced Heart Failure Program, Medstar Washington Hospital Center , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hockstein","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Medstar Washington Hospital Center , Washington DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kadakkal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Advanced Heart Failure Program, Medstar Washington Hospital Center , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-5889","authenticated-orcid":false,"given":"Mark","family":"Hofmeyer","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine , Washington, DC, USA"},{"name":"Department of Cardiology, Advanced Heart Failure Program, Medstar Washington Hospital Center , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Advanced Heart Failure Program, Medstar Washington Hospital Center , Washington, DC, 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