{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:27:58Z","timestamp":1773804478617,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Very low birthweight (&amp;lt;1500 g, VLBW) infants with severe congenital heart defect (CHD) are at increased risk for perinatal and operative mortality. This study aims to describe morbidity, long-term mortality and neuro-developmental outcome in early childhood in VLBW infants who received cardiac surgery for severe CHD within 1 year after birth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Monocentric observational study on VLBW infants with severe CHD born between 2008 and 2017. Neurodevelopmental impairment at 2 years corrected age was defined as cognitive deficit, cerebral palsy or major neurosensory deficit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 24 patients were included. Twenty-one (87.5%) infants underwent cardiac surgery with hypothermia during cardiopulmonary bypass (median temperature 30.3\u00b0C, interquartile range 27.0\u201332.0\u00b0C) at a median age of 96 (40\u2013188) days. Seven (29.2%, 95% confidence interval 14.9\u201349.2%) patients died within the first year after cardiac surgery. Survival rates decreased with increasing STAT mortality category of the surgical procedure. Neurodevelopmental impairment at 2 years of corrected age was found in 9 out of 17 (52.9%) surviving infants, with 8 infants (47.1%) presenting with a cognitive deficit or delay and 4 infants (23.5%) being diagnosed with cerebral palsy. Survival without neuro-developmental impairment was 29.2% (n = 7, 95% confidence interval 14.9\u201349.2%) in the entire study cohort. Eighty percent of the newborns with dextro-transposition of the great arteries, but no patient with univentricular anatomy, survived without neuro-developmental impairment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Individual VLBW infants with severe CHD may develop well despite the high combined risk for adverse outcomes. The type of cardiac malformation may affect early- and long-term outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab494","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T11:08:27Z","timestamp":1635419307000},"source":"Crossref","is-referenced-by-count":7,"title":["Outcomes in very low birthweight infants with severe congenital heart defect following cardiac surgery within the first year of life"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-4861","authenticated-orcid":false,"given":"Vinzenz","family":"Boos","sequence":"first","affiliation":[{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin , Berlin, Germany"},{"name":"Department of Neonatology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin , Berlin, Germany"},{"name":"Department of Neonatology, Hospital Zollikerberg , Zollikerberg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-1557","authenticated-orcid":false,"given":"Felix","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin , Berlin, Germany"},{"name":"German Center for Cardiovascular Research, Congenital Heart Diseases , Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery\/Pediatric Heart Surgery, German Heart Center Berlin , Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3140-9154","authenticated-orcid":false,"given":"Joachim","family":"Photiadis","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery\/Pediatric Heart Surgery, German Heart Center Berlin , 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