{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:48:02Z","timestamp":1787064482836,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The effect of ischaemic postconditioning (IPost) on postcardioplegic cardiac function is not known. We hypothesized that IPost was cardioprotective in adult patients undergoing elective aortic valve replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a multicentre, prospective, randomized trial, patients (n\u2009=\u2009209) were randomized to either a standard operation (controls) or postconditioning. Immediately before the cross-clamp was released, patients in the postconditioning group underwent 3 cycles of flow\/non-flow (2 min each) of normothermic blood via the antegrade cardioplegia line. The primary end point was cardiac index. Secondary end points included additional haemodynamic measurements, biomarkers of cardiomyocyte injury, renal function parameters, intra- and postoperative arrhythmias and use of inotropic agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>There was no significant difference between the groups regarding cardiac index [mean between-group difference, 95% confidence interval (CI), 0.11 (\u22120.1 to 0.3), P\u2009=\u20090.27]. Postconditioning had no effect on other haemodynamic parametres. There was no between-group difference regarding troponin T or creatine kinase MB. Postconditioning reduced the relative risk for arrhythmias by 45% (P\u2009=\u20090.03) when postoperative atrial fibrillation and intraoperative ventricular fibrillation were combined. There were no differences in patients with\/without diabetes, patients above\/below 70\u2009years of age or between the centres. However, after postconditioning, the cardiac index [95% CI, 0.46 (0.2\u20130.7), P\u2009=\u20090.001], cardiac output (P\u2009&amp;lt;\u20090.001), mean arterial pressure (P\u2009&amp;lt;\u20090.001) and left ventricular stroke work index (P\u2009&amp;lt;\u20090.001) were higher in males compared to females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>IPost had no overall cardioprotective effects in patients undergoing aortic valve replacement but improved postoperative cardiac performance in men compared to women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab500","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:06:05Z","timestamp":1635725165000},"page":"1144-1152","source":"Crossref","is-referenced-by-count":5,"title":["Effects of ischaemic postconditioning in aortic valve replacement: a multicenter 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Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-3997","authenticated-orcid":false,"given":"Radoslaw","family":"Wilimski","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"Brunborg","sequence":"additional","affiliation":[{"name":"Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marte","family":"Wennemo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila","family":"Karpova","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Almazov National Medical Research Centre, Saint 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