{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T23:21:54Z","timestamp":1772061714608,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Sebastian Michel, J\u00fcrgen H\u00f6rer"},{"name":"Nikolaus Haas and Christian Hagl are members of the European EXCOR Paediatric Investigator Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>We evaluated the outcome of patients in cardiogenic shock receiving a paracorporeal pulsatile biventricular assist device as a bridge to transplantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We performed a retrospective single-centre analysis of all patients who received a Berlin Heart Excor\u00ae at our institution between 2004 and 2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 97 patients (90 adults, 7 paediatric) were analysed. Eighty-four patients were in Interagency Registry for Mechanically Assisted Circulatory Support level 1 (80 adults, 4 paediatric). Diagnoses were dilated cardiomyopathy (n\u2009=\u200941), ischaemic cardiomyopathy (n\u2009=\u200917) or myocardial infarction (n\u2009=\u20094), myocarditis (n\u2009=\u200915), restrictive cardiomyopathy (n\u2009=\u20092), graft failure after heart transplant (n\u2009=\u20097), postcardiotomy heart failure (n\u2009=\u20095), postpartum cardiomyopathy (n\u2009=\u20093), congenital heart disease (n\u2009=\u20091), valvular cardiomyopathy (n\u2009=\u20091) and toxic cardiomyopathy (n\u2009=\u20091). All patients were in biventricular heart failure and had secondary organ dysfunction. The mean duration of support was 63\u2009days (0\u2013487\u2009days). There was a significant decrease in creatinine values after assist device implantation (from 1.83\u2009\u00b1\u20090.79 to 1.12\u2009\u00b1\u20090.67\u2009mg\/dl, P\u2009=\u20090.001) as well as a decrease in bilirubin values (from 3.94\u2009\u00b1\u20094.58 to 2.65\u2009\u00b1\u20093.61\u2009mg\/dl, P\u2009=\u20090.084). Cerebral stroke occurred in 16 patients, bleeding in 15 and infection in 13 patients. Forty-eight patients died on support, while 49 patients could be successfully bridged to transplantation. Thirty-day survival and 1-year survival were 70.1% and 41.2%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>A pulsatile biventricular assist device is a reasonable therapeutic option in cardiogenic shock, when immediate high cardiac output is necessary to rescue the already impaired kidney and liver function of the patient.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab547","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T20:13:10Z","timestamp":1638821590000},"page":"942-949","source":"Crossref","is-referenced-by-count":17,"title":["Bridging patients in cardiogenic shock with a paracorporeal pulsatile biventricular assist device to heart transplantation\u2014a single-centre experience"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-860X","authenticated-orcid":false,"given":"Sebastian","family":"Michel","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Ludwig Maximilian University Munich, Munich, Germany"},{"name":"Division of Congenital Heart Surgery, Department of Cardiac Surgery, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Buchholz","sequence":"additional","affiliation":[{"name":"MediClin Heart Center, Lahr, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8749-2962","authenticated-orcid":false,"given":"Joscha","family":"Buech","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Veit","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Fabry","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Abicht","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1103-3775","authenticated-orcid":false,"given":"Nikolaus","family":"Thierfelder","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Lily","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Division of Congenital Heart Surgery, Department of Cardiac Surgery, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Pabst von Ohain","sequence":"additional","affiliation":[{"name":"Division of Congenital Heart Surgery, Department of Cardiac Surgery, Ludwig Maximilian University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Ludwig Maximilian University Munich, Munich, 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