{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:38:45Z","timestamp":1769726325749,"version":"3.49.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)\u2014Finance","award":["Code 001"],"award-info":[{"award-number":["Code 001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease that affects the pulmonary vasculature, leading to increased afterload and eventually right ventricular (RV) remodelling and failure. Bilateral sympathectomy (BS) has shown promising results in dampening cardiac remodelling and dysfunction in several heart failure models. In the present study, we investigated whether BS reduces pulmonary arterial remodelling and mitigates RV remodelling and failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>PAH was induced in male Wistar rats by intraperitoneal injection of monocrotaline. Rats were divided into 3 groups, involving untreated PAH (n\u2009=\u200915), BS-treated PAH (n\u2009=\u200913) and non-manipulated control rats (n\u2009=\u200913). Three weeks after PAH induction, the rats were anaesthetized and RV function was assessed via the pressure-volume loop catheter approach. Upon completion of the experiment, the lungs and heart were harvested for further analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>BS was found to prevent pulmonary artery remodelling, with a clear reduction in \u03b1-smooth muscle actin and endothelin-1 expression. RV end-systolic pressure was reduced in the BS group, and preload recruitable stroke work was preserved. BS, therefore, mitigated RV remodelling and cardiomyocyte hypertrophy and diminished oxidative stress.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>We showed that thoracic BS may be an important treatment option for PAH patients. Blockade of the sympathetic pathway can prevent pulmonary remodelling and protect the RV from oxidative stress, myocardial remodelling and function decay.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab549","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T20:11:22Z","timestamp":1639685482000},"page":"1337-1345","source":"Crossref","is-referenced-by-count":3,"title":["Thoracic bilateral sympathectomy attenuates oxidative stress and prevents ventricular remodelling in experimental pulmonary hypertension"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8818-5043","authenticated-orcid":false,"given":"Raphael dos Santos","family":"Coutinho e Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio Cir\u00fargico de Pesquisa Cardiovascular (LIM-11), Instituto do Cora\u00e7\u00e3o (Incor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-8365","authenticated-orcid":false,"given":"Lucas Moritz","family":"Wiggenhauser","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, Laboratory for Cardiovascular Regenerative Medicine, University Medical Center Groningen, University of Groningen , Groningen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-3052","authenticated-orcid":false,"given":"Rafael","family":"Simas","sequence":"additional","affiliation":[{"name":"The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet , Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-6864","authenticated-orcid":false,"given":"Fernando Luiz","family":"Zanoni","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Cir\u00fargico de Pesquisa Cardiovascular (LIM-11), Instituto do Cora\u00e7\u00e3o (Incor), Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-1214","authenticated-orcid":false,"given":"Geisla","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed, UNIVALI , Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Beatriz","family":"da Silva","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed, UNIVALI , Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8819-2155","authenticated-orcid":false,"given":"Daniel Cury","family":"Ogata","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed, UNIVALI , Santa 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