{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:27Z","timestamp":1787008707499,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The goal of this multicentre retrospective study was to compare long-term clinical and haemodynamic outcomes of the Carpentier-Edwards Magna Ease (CEME) bioprosthesis by patient age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included consecutive patients who underwent isolated and combined surgical aortic valve replacement (AVR) with CEME valve between January 2008 and March 2020 at 4 cardiac surgery centres in Italy. Survival distribution was evaluated at follow-up according to age and surgery type (combined or isolated AVR), together with freedom from structural valve deterioration (SVD), reoperation and combined events, i.e. SVD, reoperation, endocarditis and thromboembolic events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 1027 isolated and 1121 combined AVR were included; 776 patients were younger than 65\u2009years whereas 1372 were 65\u2009years or older. The 30-day Valve-Academic-Research-Consortium mortality was 2% (&amp;lt;65 years) and 6% (\u2265 65 years) (P\u2009&amp;lt;\u20090.001), whereas it was 3% for isolated AVR and 7% for combined AVR (P\u2009&amp;lt;\u20090.001). The 12-year survival was 81% for those younger than 65\u2009years vs 45% for those equal to or older than 65\u2009years (P\u2009&amp;lt;\u20090.001), whereas they were 61% vs 49% for isolated and combined AVR (P\u2009=\u20090.10). The 12-year freedom from combined events, excluding death, was 79% for those younger than 65\u2009years vs 87% for those equal to or older than (P\u2009=\u20090.51), whereas they were 83% for isolated and 86% for combined AVR (P\u2009=\u20090.10). The 12-year freedom from SVD was 93% and 93% in patients younger than 65 and those equal to or older than 65\u2009years (P\u2009=\u20090.63), and the results were comparable even in cases with isolated and combined AVR (92% vs 94%, P\u2009=\u20090.21). A multivariable Cox analysis including gender, presence of patient\u2013prosthesis mismatch, isolated AVR and age showed that only the age was an independent risk factor for the incidence of SVD (P\u2009=\u20090.029).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Outcomes from this large multicentre analysis demonstrated that a CEME bioprosthesis provides good clinical results and long-term durability even in patients younger than 65\u2009years. Furthermore, the hazard for SVD has been shown to be lower for older age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration number<\/jats:title>\n                    <jats:p>105n\/AO\/21.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab552","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T15:13:10Z","timestamp":1638803590000},"page":"888-896","source":"Crossref","is-referenced-by-count":23,"title":["Carpentier-Edwards Magna Ease bioprosthesis: a multicentre clinical experience and 12-year durability"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-8586","authenticated-orcid":false,"given":"Antonio","family":"Piperata","sequence":"first","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4029-5678","authenticated-orcid":false,"given":"Alessandro","family":"Fiocco","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-2874","authenticated-orcid":false,"given":"Andrea","family":"Cavicchiolo","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-6287","authenticated-orcid":false,"given":"Matteo","family":"Ponzoni","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2902-7947","authenticated-orcid":false,"given":"Marco","family":"Gemelli","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Gastino","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular 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Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Zanella","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6758-5232","authenticated-orcid":false,"given":"Matteo","family":"Nadali","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9654-0989","authenticated-orcid":false,"given":"Domenico","family":"Mangino","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Mestre Hospital, Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Lorenzoni","sequence":"additional","affiliation":[{"name":"Department 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