{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:52:07Z","timestamp":1789170727720,"version":"build-2803163510"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LQ20H180004"],"award-info":[{"award-number":["LQ20H180004"]}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["15\/RP\/2765"],"award-info":[{"award-number":["15\/RP\/2765"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>This study aimed to investigate the impact of mechanical factors at baseline on the patency of a restorative conduit for coronary bypass grafts in an ovine model at serial follow-up up to 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The analyses of 4 mechanical factors [i.e. bending angle, superficial wall strain and minimum and maximum endothelial shear stress (ESS)] were performed in 3D graft models reconstructed on baseline (1-month) angiograms frame by frame by a core laboratory blinded for the late follow-up. The late patency was documented by Quantitative Flow Ratio (QFR\u00ae) that reflects the physiological status of the graft. The correlation between 4 mechanical factors and segmental QFR (\u25b3QFR) were analysed on 10 equal-length segments of each graft.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 69 graft geometries of 7 animals were performed in the study. The highest \u25b3QFR at 12\u2009months was colocalized in segments of the grafts with the largest bending angles at baseline. Higher \u25b3QFR at 3\u2009months were both at the anastomotic ends and were colocalized with the highest superficial wall strain at baseline. High baseline ESS was topographically associated with higher \u25b3QFR at the latest follow-up. Correlations of minimum and maximum ESS with \u25b3QFR at 3\u2009months were the strongest among these parameters (\u03c1\u2009=\u20090.30, 95% CI [\u22120.05 to 0.56] and \u03c1\u2009=\u20090.27, 95% CI [\u22120.05 to 0.54], respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Despite the limited number of grafts, this study suggests an association between early abnormal mechanical factors and late flow metrics of the grafts. The understanding of the mechanical characteristics could help to improve this novel conduit.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezab554","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T20:08:42Z","timestamp":1639253322000},"page":"1402-1411","source":"Crossref","is-referenced-by-count":7,"title":["One-year performance of biorestorative polymeric coronary bypass grafts in an ovine model: correlation between early biomechanics and late serial Quantitative Flow Ratio"],"prefix":"10.1093","volume":"61","author":[{"given":"Xinlei","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital of Wenzhou Medical University , Wenzhou, China"},{"name":"Department of Cardiology, National University of Ireland Galway (NUIG) , Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-5648","authenticated-orcid":false,"given":"Masafumi","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland Galway (NUIG) , Galway, Ireland"},{"name":"Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Center , Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric K W","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent\u2019s Hospital, Melbourne Medical School, University of Melbourne , Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland Galway (NUIG) , Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9479-8719","authenticated-orcid":false,"given":"Ryo","family":"Torii","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University College London , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes P","family":"Janssen","sequence":"additional","affiliation":[{"name":"Medis Medical Imaging Systems BV , Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-6881","authenticated-orcid":false,"given":"Shuang Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Melbourne School of Engineering, University of Melbourne , Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Vijgeboom","sequence":"additional","affiliation":[{"name":"Medis Medical Imaging Systems BV , Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S","family":"El-Kurdi","sequence":"additional","affiliation":[{"name":"Xeltis BV , Eindhoven, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Cox","sequence":"additional","affiliation":[{"name":"Xeltis BV , Eindhoven, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Rein\u00f6hl","sequence":"additional","affiliation":[{"name":"Xeltis BV , Eindhoven, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-3731","authenticated-orcid":false,"given":"Jouke","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center , Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Barlis","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent\u2019s Hospital, Melbourne Medical School, University of Melbourne , Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-4376","authenticated-orcid":false,"given":"William","family":"Wijns","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland Galway (NUIG) , Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan H C","family":"Reiber","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center , Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos V","family":"Bourantas","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London , London, UK"},{"name":"Department of Cardiology, Barts Heart Centre , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[{"name":"CVPath Institute, Inc , Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Onuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland Galway (NUIG) , Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-1104","authenticated-orcid":false,"given":"Patrick W","family":"Serruys","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University of Ireland Galway (NUIG) , Galway, Ireland"},{"name":"National Heart & Lung Institute, Imperial College London , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"2022053118490576800_ezab554-B1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.athoracsur.2015.09.100","article-title":"The Society of Thoracic Surgeons clinical practice guidelines on arterial conduits for coronary artery bypass grafting","volume":"101","author":"Aldea","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"2022053118490576800_ezab554-B2","first-page":"435","article-title":"Biomechanics and biocompatibility of the perfect conduit-can we build one?","volume":"2","author":"Byrom","year":"2013","journal-title":"Ann Cardiothorac Surg"},{"key":"2022053118490576800_ezab554-B3","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1093\/eurheartj\/ehq318","article-title":"Randomized trial to compare bilateral vs. single internal mammary coronary artery bypass grafting: 1-year results of the Arterial Revascularisation Trial (ART)","volume":"31","author":"Taggart","year":"2010","journal-title":"Eur Heart J"},{"key":"2022053118490576800_ezab554-B4","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1056\/NEJMoa0804626","article-title":"Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease","volume":"360","author":"Serruys","year":"2009","journal-title":"N Engl J Med"},{"key":"2022053118490576800_ezab554-B5","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.21037\/jtd-19-739","article-title":"Total cavopulmonary connection with a new restorative vascular graft: results at 2 years","volume":"12","author":"Bockeria","year":"2020","journal-title":"J Thorac Dis"},{"key":"2022053118490576800_ezab554-B6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0741-5214(97)70289-1","article-title":"Computational design of a bypass graft that minimizes wall shear stress gradients in the region of the distal anastomosis","volume":"25","author":"Lei","year":"1997","journal-title":"J Vasc Surg"},{"key":"2022053118490576800_ezab554-B7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1089\/ten.teb.2015.0100","article-title":"The tissue-engineered vascular graft\u2014past, present, and future","volume":"22","author":"Pashneh-Tala","year":"2016","journal-title":"Tissue Eng B: Rev"},{"key":"2022053118490576800_ezab554-B8","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10554-018-1311-7","article-title":"Assessment of superficial coronary vessel wall deformation and stress: validation of in silico models and human coronary arteries in vivo","volume":"34","author":"Wu","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"key":"2022053118490576800_ezab554-B9","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1093\/eurheartj\/ehz551","article-title":"Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications","volume":"40","author":"Gijsen","year":"2019","journal-title":"Eur Heart J"},{"key":"2022053118490576800_ezab554-B10","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.jcin.2016.07.013","article-title":"Diagnostic accuracy of fast computational approaches to derive fractional flow reserve from diagnostic coronary angiography: the international multicenter FAVOR Pilot Study","volume":"9","author":"Tu","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"2022053118490576800_ezab554-B11","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1126\/science.278.5343.1601","article-title":"Reversible polymers formed from self-complementary monomers using quadruple hydrogen bonding","volume":"278","author":"Sijbesma","year":"1997","journal-title":"Science"},{"key":"2022053118490576800_ezab554-B12","doi-asserted-by":"crossref","first-page":"e1099","DOI":"10.4244\/EIJ-D-16-01020","article-title":"A novel four-dimensional angiographic approach to assess dynamic superficial wall stress of coronary arteries in vivo: initial experience in evaluating vessel sites with subsequent plaque rupture","volume":"13","author":"Wu","year":"2017","journal-title":"EuroIntervention"},{"key":"2022053118490576800_ezab554-B13","doi-asserted-by":"crossref","first-page":"667310","DOI":"10.3389\/fcvm.2021.667310","article-title":"Angiography-based 4-dimensional superficial wall strain and stress: a new diagnostic tool in the catheterization laboratory","volume":"8","author":"Wu","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2022053118490576800_ezab554-B14","doi-asserted-by":"crossref","first-page":"051006","DOI":"10.1115\/1.4039306","article-title":"Elevated blood viscosity and microrecirculation resulting from coronary stent malapposition","volume":"140","author":"Poon","year":"2018","journal-title":"J Biomech Eng"},{"key":"2022053118490576800_ezab554-B15","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0741-5214(92)90019-5","article-title":"Anastomotic intimal hyperplasia: mechanical injury or flow induced","volume":"15","author":"Bassiouny","year":"1992","journal-title":"J Vasc Surg"},{"key":"2022053118490576800_ezab554-B16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1115\/1.2895739","article-title":"The effect of angle and flow rate upon hemodynamics in distal vascular graft anastomoses: a numerical model study","volume":"116","author":"Fei","year":"1994","journal-title":"J Biomech Eng"},{"key":"2022053118490576800_ezab554-B17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ejvs.2006.01.006","article-title":"The mechanical properties of infrainguinal vascular bypass grafts: their role in influencing patency","volume":"31","author":"Sarkar","year":"2006","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2022053118490576800_ezab554-B18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1053\/ejvs.2002.1810","article-title":"Improving the patency of vascular bypass grafts: the role of suture materials and surgical techniques on reducing anastomotic compliance mismatch","volume":"25","author":"Tiwari","year":"2003","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2022053118490576800_ezab554-B19","first-page":"359","article-title":"Long-term graft patency after coronary artery bypass grafting: effects of surgical technique","volume":"17","author":"Tinica","year":"2019","journal-title":"Exp Ther Med"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/61\/6\/1402\/43868525\/ezab554.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/61\/6\/1402\/43868525\/ezab554.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T20:07:00Z","timestamp":1654027620000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/61\/6\/1402\/6504031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,1,12]]},"published-print":{"date-parts":[[2022,5,27]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezab554","relation":{},"ISSN":["1010-7940","1873-734X"],"issn-type":[{"value":"1010-7940","type":"print"},{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,1,12]]}}}