{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:18:36Z","timestamp":1792001916346,"version":"4.4.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to analyse the outcomes of an international cohort of patients affected by Masaoka stage III thymic epithelial tumours with vascular involvement and treated by surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Study design was the observational multicentre retrospective cohort study. Data were extracted from the European Society of Thoracic Surgeons thymic database; additional variables were collected. Inclusion criteria were as follows: stage III (Masaoka\u2013Koga) thymic epithelial tumours; surgery with radical intention; clinical or pathological great vessels involvement; and radiologically suspected or diagnosed intraoperatively. Outcome items were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Sixty-five patients submitted to surgery from 2001 to 2017 fulfilled inclusion criteria. Thymoma and thymic carcinoma patients did not differ for demographics and clinical characteristics. The majority of great vessel treated were superior vena cava or innominate veins (72.3%). Eleven patients (16.9%) had postoperative cardiopulmonary complications; vascular stenosis was observed in 3 patients (4.6%). The multivariable Cox analysis for disease-free survival showed an increased hazard of recurrence for thymic carcinoma (hazard ratio = 3.59; 95% confidence interval: 1.66\u20137.78, P = 0.001). The 1-, 3-, 5- and 10-year overall survival rates were 0.86, 0.84, 0.81, and 0.53, respectively. There was no significant difference in overall survival according to resection status or between thymoma and thimic carcinoma. The univariable Cox regression model did not show an increased hazard of death for myasthenic patients considering all resection status and for patients who received neoadjuvant therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>We observed that clinical outcomes of patients treated for stage III thymic epithelial tumours with vascular involvement are satisfactory suggesting to increase the confidence in dealing with these complex surgeries. Complete resection should be achieved, even though extensive vascular reconstructions are required.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac021","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T20:09:49Z","timestamp":1641845389000},"source":"Crossref","is-referenced-by-count":12,"title":["Surgical resection of Masaoka stage III thymic epithelial tumours with great vessels involvement: a retrospective multicentric analysis from the European Society of Thoracic Surgeons thymic database"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-6244","authenticated-orcid":false,"given":"Paolo","family":"Mendogni","sequence":"first","affiliation":[{"name":"Thoracic Surgery and Lung Transplant Unit, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8317-2339","authenticated-orcid":false,"given":"Alper","family":"Toker","sequence":"additional","affiliation":[{"name":"Istanbul University, Istanbul Medical School Department of Thoracic Surgery , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6037-5475","authenticated-orcid":false,"given":"Bernhard","family":"Moser","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-0593","authenticated-orcid":false,"given":"Florentino Hernando","family":"Trancho","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, Universidad Complutense Madrid , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-991X","authenticated-orcid":false,"given":"Clemens","family":"Aigner","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ruhrlandklinik\u2014West German Lung Center, University Hospital Essen , Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-9534","authenticated-orcid":false,"given":"Ivan Gomes","family":"Bravio","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Francisco Gentil Portuguese Institute of Oncology CUF Infante Santo Hospital , Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0124-6347","authenticated-orcid":false,"given":"Nuria Maria","family":"Novoa","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Service, Salamanca University Hospital and School of Medicine , Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-2715","authenticated-orcid":false,"given":"Laureano","family":"Molins","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Clinic, Barcelona University , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Costardi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University of Torino , Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-859X","authenticated-orcid":false,"given":"Luca","family":"Voltolini","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Careggi University Hospital , Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-0484","authenticated-orcid":false,"given":"Nicoletta Pia","family":"Ard\u00f2","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, University Hospital\u2014\u201cPoliclinico Riuniti\u201d , Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Verdonck","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Vascular Surgery, Antwerp University Hospital and Antwerp University , Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-299X","authenticated-orcid":false,"given":"Luca","family":"Ampollini","sequence":"additional","affiliation":[{"name":"Thoracic Surgery, Department of Medicine and Surgery, University Hospital of Parma , Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlambos","family":"Zisis","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Athens Evangelismos Hospital , Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5629-340X","authenticated-orcid":false,"given":"Vitaly","family":"Barmin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, P.A. 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