{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:57:33Z","timestamp":1784606253630,"version":"3.55.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Association for Cardio-Thoracic Surgery, EACTS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Atrial fibrillation (AF) is a risk factor for mortality and cerebrovascular accidents (CVAs) and is common in patients with heart failure. This study evaluated survival and adverse events in patients with a left ventricular assist device (LVAD) and a history of AF in the European Registry for Patients with Mechanical Circulatory Support.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Patients with a continuous-flow LVAD, AF or sinus rhythm (SR) and a follow-up were included. Kaplan\u2013Meier analyses for survival (including a propensity-scored matched analysis), freedom from CVA, pump thrombosis, bleeding and a composite of pump thrombosis\/CVA were performed. To correct for covariate imbalance, a Kaplan-Meier (KM) analysis was performed after propensity score (PS) matching the groups. Finally, a Cox regression was performed for predictors of lower survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Overall, 1821 patients (83% male) were included, with a median age of 57\u2009years and a median follow-up of 13.1\u2009months (interquartile range: 4.3\u201327.7). Preoperative Electrocardiogram (ECG) rhythm was AF in 421 (23.1%) and SR in 1400 (76.9%) patients. Patients with pre-LVAD AF had a lower \u226490-day (81.9% vs 87.1%, P\u2009=\u20090.0047) and 4-year (35.4% vs 44.2%, P\u2009=\u20090.0083) survival compared to SR. KM analysis with PS matching groups revealed a trend (P\u2009=\u20090.087) towards decreased survival. Univariable analyses confirmed pre-LVAD AF as a predictor for mortality, but the multivariable analysis did not. No difference in the rate of adverse events was found. An analysis of patients at 24 months revealed a higher rate of CVAs for pre-LVAD AF patients (77% vs 94.3%, P\u2009&amp;lt;\u20090.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Patients with pre-LVAD AF undergoing LVAD implantation had a worse survival. However, after performing a multivariate analysis, and PS matching analysis, AF was no longer significant, indicating a worser preoperative condition in these patients. Concerning thrombo-embolic events, only patients with pre-LVAD AF alive beyond 24\u2009months have a higher risk of CVAs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac023","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T20:09:49Z","timestamp":1641845389000},"page":"1164-1175","source":"Crossref","is-referenced-by-count":13,"title":["Survival and adverse events in patients with atrial fibrillation at left ventricular assist device implantation: an analysis of the European Registry for Patients with Mechanical Circulatory Support"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-9911","authenticated-orcid":false,"given":"Christiaan F J","family":"Antonides","sequence":"first","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-1518","authenticated-orcid":false,"given":"Yunus C","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands"},{"name":"Department of Cardiology, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-8384","authenticated-orcid":false,"given":"Kevin M","family":"Veen","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7277-8554","authenticated-orcid":false,"given":"Rahatullah","family":"Muslem","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-3348","authenticated-orcid":false,"given":"Theo M M H","family":"De By","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands"},{"name":"European Association for Cardio-Thoracic Surgery, EUROMACS, Windsor, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-1998","authenticated-orcid":false,"given":"Ad J J C","family":"Bogers","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, 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