{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:10:19Z","timestamp":1793239819584,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100022438","name":"European Association for Cardio-Thoracic Surgery","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022438","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>In the third report of the European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery, outcomes of patients receiving mechanical circulatory support are reviewed in relation to implant era.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Procedures in adult patients (January 2011\u2013June 2020) were included. Patients from centres with &amp;lt;60% follow-ups completed were excluded. Outcomes were stratified into 3 eras (2011\u20132013, 2014\u20132017 and 2018\u20132020). Adverse event rates (AERs) were calculated and stratified into early phase (&amp;lt;3 months) and late phase (&amp;gt;3 months). Risk factors for death were explored using univariable Cox regression with a stepwise time-varying hazard ratio (&amp;lt;3 vs &amp;gt;3 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In total, 4834 procedures in 4486 individual patients (72 hospitals) were included, with a median follow-up of 1.1 (interquartile range: 0.3\u20132.6) years. The annual number of implants (range: 346\u2013600) did not significantly change (P = 0.41). Both Interagency Registry for Mechanically Assisted Circulatory Support class (classes 4\u20137: 23, 25 and 33%; P &amp;lt; 0.001) and in-hospital deaths (18.5, 17.2 and 11.2; P &amp;lt; 0.001) decreased significantly between eras. Overall, mortality, transplants and the probability of weaning were 55, 25 and 2% at 5 years after the implant, respectively. Major infections were mainly noted early after the implant occurred (AER&amp;lt;3 months: 1.44 vs AER&amp;gt;3 months: 0.45). Bilirubin and creatinine levels were significant risk factors in the early phase but not in the late phase after the implant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In its 10 years of existence, EUROMACS has become a point of reference enabling benchmarking and outcome monitoring. Patient characteristics and outcomes changed between implant eras. In addition, both occurrence of outcomes and risk factor weights are time dependent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac032","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T15:11:25Z","timestamp":1641913885000},"source":"Crossref","is-referenced-by-count":39,"title":["The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-3348","authenticated-orcid":false,"given":"Theo M M H","family":"de By","sequence":"first","affiliation":[{"name":"EUROMACS, EACTS House , Windsor, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-1295","authenticated-orcid":false,"given":"Felix","family":"Schoenrath","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, 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