{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:33:59Z","timestamp":1789259639095,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The goal of this study was to evaluate the surgical outcomes of a valve-sparing root replacement using the reimplantation technique for annuloaortic ectasia in patients with Marfan syndrome (MFS) and in those with Loeys-Dietz syndrome (LDS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We reviewed 103 patients with MSF with mutations in the fibrillin-1 gene and 28 patients with LDS with mutations in the transforming growth factor-beta receptor and 2, SMAD3 and transforming growth factor beta-2 from 1988 to 2020.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Forty-four (42.7%) patients with MFS [26 men, 31 (7.6) years] and 10 (35.7%) patients with Loeys-Dietz syndrome (LDS) [7 men, 22 (standard deviation: 8.6) years] who had no aortic dissection and underwent valve-sparing root replacement were included. The preoperative sinus diameter [46 (45\u201350.5) mm in those with MFS vs 48 (47\u201350) mm in those with LDS, p\u2009=\u20090.420] and the percentage of aortic insufficiency &amp;gt; grade 2+ [31.8% (10\/44) in patients with MFS vs 10.0% (1\/10) in those with LDS, p\u2009=\u20090.667] revealed no significant differences between the 2 groups. The cumulative incidences of aortic insufficiency greater than grade 1 (p\u2009=\u20090.588) and aortic valve reoperation (p\u2009=\u20090.310) were comparable between the 2 groups. Patients with LDS had a higher tendency towards aortic dissection after the initial operation (p\u2009=\u20090.061) and a significantly higher cumulative incidence of aortic reoperation (p\u2009=\u20090.003) versus those with MFS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Patients with MFS and those with LDS showed similar cumulative incidences of recurrent aortic valve insufficiency and aortic valve reoperation. Those with LDS revealed a higher cumulative incidence of aortic reoperation and a greater tendency towards aortic dissection after the initial operation compared with those with MFS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac050","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T12:08:51Z","timestamp":1643371731000},"page":"1318-1325","source":"Crossref","is-referenced-by-count":5,"title":["Long-term durability of a reimplantation\u00a0valve-sparing aortic root replacement can be expected in both Marfan syndrome and Loeys-Dietz syndrome"],"prefix":"10.1093","volume":"61","author":[{"given":"Yoshimasa","family":"Seike","sequence":"first","affiliation":[{"name":"National Cerebral and Cardiovascular Center, Department of Cardiovascular Surgery , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Yokawa","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center, Department of Cardiovascular Surgery , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Koizumi","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center, Department of Cardiovascular Surgery , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Masada","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center, Department of Cardiovascular Surgery , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-9255","authenticated-orcid":false,"given":"Yosuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center, Department of Cardiovascular Surgery , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6956-6374","authenticated-orcid":false,"given":"Hiroko","family":"Morisaki","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute, Department of Medical Genetics , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Morisaki","sequence":"additional","affiliation":[{"name":"The University of Tokyo, Division of Molecular Pathology, the Institute of Medical Science , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center, Department of Cardiovascular Surgery , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8378-2391","authenticated-orcid":false,"given":"Hitoshi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center, Department of Cardiovascular Surgery , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"2022053118490440800_ezac050-B1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0022-5223(19)34942-6","article-title":"An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ascending aorta","volume":"103","author":"David","year":"1992","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022053118490440800_ezac050-B2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/352337a0","article-title":"Marfan syndrome caused by a recurrent de novo missense mutation in the 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