{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:14:31Z","timestamp":1791980071874,"version":"4.4.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Landspitali University Hospital Science Fund","award":["A2021-038"],"award-info":[{"award-number":["A2021-038"]}]},{"name":"Icelandic Student Innovation Fund","award":["2219224\u20131101"],"award-info":[{"award-number":["2219224\u20131101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>We assessed adherence to statins, beta-blockers and renin\u2013angiotensin system (RAS) inhibitors after coronary artery bypass graft surgery and factors associated with non-adherence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This nationwide retrospective cohort study included all individuals undergoing coronary artery bypass surgery from 22 May 2007 to 20 December 2018, at Landspitali\u2014the National University Hospital (n\u2009=\u20091536). Data on dispensed prescriptions were retrieved from the National Prescription Medicine Registry. Adherence was estimated by the proportion of days covered up to 2 years after hospital discharge, with cut-offs for strict adherence and non-adherence at over 80% and under 50%, respectively. Multivariable logistic regression was used to assess variables associated with non-adherence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Criteria for strict adherence were met by 39.2%, 36.9% and 30.1% of patients for statins, beta-blockers and RAS inhibitors, respectively. Non-adherence criteria were met for 14.4%, 25.9% and 43.6% of patients for statins, beta-blockers and RAS inhibitors, respectively. High Hospital Frailty Risk Score Class (statins: odds ratio (OR) 2.29, confidence interval (CI) 1.02\u20134.86; RAS inhibitors: OR 2.06, CI 1.04\u20134.04), concomitant aortic valve replacement (statins: OR 1.64, CI 1.11\u20132.38; RAS inhibitors: OR 1.78, CI 1.26\u20132.52) and a new prescription for a medication class following surgery (statins: OR 2.87, CI 2.06\u20134.01; beta-blockers: OR 1.70, CI 1.32\u20132.18; RAS inhibitors: OR 6.95, CI 5.27\u20139.25) were associated with non-adherence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Non-adherence to medical therapy after coronary artery bypass surgery is common. Patients with a higher burden of frailty and patients naive to the medical treatment of coronary artery disease should be a target group for efforts to increase medication adherence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac054","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T20:11:34Z","timestamp":1643055094000},"source":"Crossref","is-referenced-by-count":6,"title":["A retrospective study on adherence to secondary prevention medications after coronary bypass surgery"],"prefix":"10.1093","volume":"62","author":[{"given":"Leon Arnar","family":"Heitmann","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Iceland , Reykjav\u00edk, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5475-5044","authenticated-orcid":false,"given":"Ingibjorg Jona","family":"Gudmundsdottir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland , Reykjav\u00edk, Iceland"},{"name":"Department of Cardiology, Landspitali\u2014the National University Hospital , Reykjav\u00edk, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-6723","authenticated-orcid":false,"given":"Freyja","family":"Jonsdottir","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Iceland , Reykjav\u00edk, Iceland"},{"name":"Hospital Pharmacy, Landspitali\u2014the National University Hospital , Reykjav\u00edk, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Gudbjartsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland , Reykjav\u00edk, Iceland"},{"name":"Department of Cardiothoracic Surgery, Landspitali\u2014the National University Hospital , Reykjav\u00edk, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7054-0844","authenticated-orcid":false,"given":"Martin Ingi","family":"Sigurdsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland , Reykjav\u00edk, Iceland"},{"name":"Department of Anesthesiology and Critical Care Medicine, Landspitali\u2014the National University Hospital , Reykjav\u00edk, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"2022093019001051400_ezac054-B1","first-page":"e652","article-title":"ACCF\/AHA Guideline for coronary artery bypass graft surgery","volume":"124","author":"Hillis","year":"2011","journal-title":"Circulation"},{"key":"2022093019001051400_ezac054-B2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic 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