{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T12:28:01Z","timestamp":1775824081073,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"CORCYM S.r.l."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Sutureless aortic valves demonstrated non-inferiority to standard stented valves for major cardiovascular and cerebral events at 1 year after aortic valve replacement. We aim to assess the factors correlating with permanent pacemaker implantation (PPI) in both cohorts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>PERSIST-AVR is a prospective, randomized, open-label trial. Patients undergoing aortic valve replacement were randomized to receive a sutureless aortic valve replacement (Su-AVR) or stented sutured bioprosthesis (SAVR). Multivariable analysis was performed to identify possible independent risk factors associated with PPI. A logistic regression analysis was performed to estimate the risk of PPI associated to different valve size.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The 2 groups (Su-AVR; n = 450, SAVR n = 446) were well balanced in terms of preoperative risk factors. Early PPI rates were 10.4% in the Su-AVR group and 3.1% in the SAVR. PPI prevalence correlated with valve size XL (P = 0.0119) and preoperative conduction disturbances (P = 0.0079) in the Su-AVR group. No predictors were found in the SAVR cohort. Logistic regression analysis showed a significantly higher risk for PPI with size XL compared to each individual sutureless valve sizes [odds ratio (OR) 0.272 vs size S (95%confidence interval 0.07\u20130.95), 0.334 vs size M (95% CI 0,16\u20130; 68), 0.408 vs size L (95% CI 0,21\u20130.81)] but equivalent risk of PPI rates for all other combination of valve sizes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Su-AVR is associated with higher PPI rate as compared to SAVR. However, the increased PPI rate appears to be size-dependent with significant higher rate only for size XL. The combination of preoperative conduction disorder and a size XL can lead to a higher probability of early PPI in Su-AVR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration number<\/jats:title>\n                  <jats:p>NCT02673697.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac164","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T12:10:51Z","timestamp":1645791051000},"source":"Crossref","is-referenced-by-count":10,"title":["Pacemaker implantation after sutureless or stented valve: results from a controlled randomized trial"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-2045","authenticated-orcid":false,"given":"Roberto","family":"Lorusso","sequence":"first","affiliation":[{"name":"Cardio-Thoracic Surgery Department, Heart & Vascular Centre, Maastricht University Medical Center+ (MUMC+) , Maastricht, Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) , Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4744-3629","authenticated-orcid":false,"given":"Justine M","family":"Ravaux","sequence":"additional","affiliation":[{"name":"Cardio-Thoracic Surgery Department, Heart & Vascular Centre, Maastricht University Medical Center+ (MUMC+) , Maastricht, Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) , Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-532X","authenticated-orcid":false,"given":"Francesco","family":"Pollari","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Cardiovascular Center, Paracelsus Medical University-Klinikum N\u00fcrnberg , Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry A","family":"Folliguet","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery & Transplantation, Assistance Publique, H\u00f4pital Henri Mondor, Universit\u00e9 Paris 12 UPEC , Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-7570","authenticated-orcid":false,"given":"Utz","family":"Kappert","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Dresden Heart Centre University Hospital, Dresden University of Technology , Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Meuris","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Universitaire Ziekenhuizen Leuven , Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malakh L","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Hannover Medical School , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric E","family":"Roselli","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic , Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7656-5812","authenticated-orcid":false,"given":"Nikolaos","family":"Bonaros","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Innsbruck Medical University , Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Fabre","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery of Artois, Hospital Center of Lens , Lens, France"},{"name":"Department of Cardiac Surgery, Bois Bernard Private Hospital, Ramsay G\u00e9n\u00e9rale de Sant\u00e9 , Lens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Corbi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Cardio-Vascular Center, University Hospital of Poitiers , Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Troise","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Poliambulanza Foundation , Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-5432","authenticated-orcid":false,"given":"Martin","family":"Andreas","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Pinaud","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, CHU d\u2019Angers, University Hospital Angers , Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Cardiovascular Center, Paracelsus Medical University-Klinikum N\u00fcrnberg , Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-1432","authenticated-orcid":false,"given":"Sami","family":"Kueri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart Center Freiburg Bad Krozingen , Bad Krozingen, Germany"},{"name":"Department of Cardiovascular Surgery, University Heart Center, Albert-Ludwigs-Universit\u00e4t Freiburg, Bad Krozingen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0640-4201","authenticated-orcid":false,"given":"Erwin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Catharina Hospital , Eindhoven, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Voisine","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universit\u00e9 Laval , Qu\u00e9bec, QC, Canada"},{"name":"Division of Cardiac Surgery, Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec (IUCPQ) , Qu\u00e9bec, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-4244","authenticated-orcid":false,"given":"Evaldas","family":"Girdauskas","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg , Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-2302","authenticated-orcid":false,"given":"Filip","family":"Rega","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Universitaire Ziekenhuizen Leuven , Leuven, Belgium"},{"name":"Division of Experimental Cardiac Surgery, Department of Cardiovascular Sciences, University of Leuven , Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-0844","authenticated-orcid":false,"given":"Julio","family":"Garcia-Puente","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hospital Universitario Virgen de la Arraixaca , Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9781-3590","authenticated-orcid":false,"given":"Theodor","family":"Fischlein","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Cardiovascular Center, Paracelsus Medical University-Klinikum N\u00fcrnberg , Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf the PERSIST-AVR 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