{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:04:52Z","timestamp":1784297092028,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Reports on gender-related differences in perioperative characteristics and the outcome after surgery for type A acute aortic dissection are contradictory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Perioperative characteristics, outcome and overall or itemized failure-to-rescue rates were collected retrospectively and dichotomized by gender in patients operated on at 5 referral institutions. A propensity score matched analysis was performed to compared males and females with similar preoperative risk profiles. Multivariable analysis assessed gender-related predictors of 30-day mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 1271 patients were collected. Females (on average, 63\u2009years old) developed type A acute aortic dissection, with differences in clinical presentation (number of intimal tears, thoracic pain at the onset of symptoms). Female-reported characteristics included lower frozen elephant trunk and elephant trunk procedures, higher femoral perfusion, retrograde cerebral perfusion and retrograde cardiopulmonary bypass restart after deep hypothermic circulatory arrest (P\u2009&amp;lt;\u20090.05). The 30-day mortality was 19.8%, without a gender-related difference (P\u2009=\u20090.37). No substantial differences in hospital outcome and in items related to failure to rescue were reported. A total of 256 propensity score matched pairs of males and females were investigated. Previous differences in surgical techniques and strategies were still confirmed; however, a higher incidence of postoperative permanent coma (P\u2009=\u20090.02) was reported in the female population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Different surgical techniques and operative strategies were used on the 2 genders, with a lower complexity in females. However, there were no differences in hospital outcome between genders, except for the higher incidence of coma in female patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac218","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T20:09:31Z","timestamp":1647893371000},"source":"Crossref","is-referenced-by-count":12,"title":["Gender-related presentation, surgical treatment, outcome and failure to rescue after surgery for type A aortic dissection: results from a multicentre registry"],"prefix":"10.1093","volume":"62","author":[{"given":"Alessandra","family":"Francica","sequence":"first","affiliation":[{"name":"Department of Surgery, Dentistry, Paediatrics, and Gynaecology; Division of Cardiac Surgery, University of Verona Medical School , Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Vendramin","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Universitaria Friuli Centrale, Cardiothoracic Department , Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1032-9155","authenticated-orcid":false,"given":"Stefano","family":"Salizzoni","sequence":"additional","affiliation":[{"name":"University of Turin\u2014Citt\u00e0 della Salute e della Scienza , Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"D\u2019Onofrio","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera, Universit\u00e0 di Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9996-6133","authenticated-orcid":false,"given":"Giuseppe","family":"Gatti","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Universitaria Giuliana Isontina , Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"University of Turin\u2014Citt\u00e0 della Salute e della Scienza , Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-699X","authenticated-orcid":false,"given":"Gino","family":"Gerosa","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera, Universit\u00e0 di Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniello","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Universitaria Giuliana Isontina , Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugolino","family":"Livi","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Universitaria Friuli Centrale, Cardiothoracic Department , Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-5761","authenticated-orcid":false,"given":"Giuseppe","family":"Faggian","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Paediatrics, and Gynaecology; Division of Cardiac Surgery, University of Verona Medical School , Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0879-3557","authenticated-orcid":false,"given":"Francesco","family":"Onorati","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Paediatrics, and Gynaecology; Division of Cardiac Surgery, University of Verona Medical School , Verona, 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