{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:18:46Z","timestamp":1792001926895,"version":"4.4.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Thymic epithelial neoplasms (TENs) represent a heterogeneous group of rare thoracic malignancies. We analysed the clinicopathological features, survival outcomes, risk factors, and patterns of recurrence in patients undergoing resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Records were reviewed for adult patients with TEN who underwent resection from 2006 to 2019. Survival rates were assessed using the Kaplan\u2013Meier method. Univariable and multivariable analyses were performed using the log-rank test and Cox proportional hazards model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 100 patients were analysed (51 females, median age 58\u2009years). Thymoma was the most common histology (n\u2009=\u200992), followed by thymic carcinoma (n\u2009=\u20095) and thymic neuroendocrine tumour (n\u2009=\u20093). Stage II (Masaoka) tumours were most common (n\u2009=\u200951), followed by stage I (n\u2009=\u200927). World Health Organization B2\/B3 was the most prominent histological subtype (n\u2009=\u200934). Complete resection (R0) was achieved in 91 patients: 86\/92 thymoma, 4\/5 thymic carcinoma and 1\/3 neuroendocrine tumour. The most common treatment modality was surgery alone in 72 patients, followed by surgery and radiation therapy in 24, and adjuvant chemoradiotherapy in 3 patients. Only one patient with thymic carcinoma received neoadjuvant chemotherapy. The 10-year overall and disease-free survival rates were 86.6% and 83.9%, respectively. Recurrence was most common in neuroendocrine tumours (3\/3). Risk factors for recurrence identified on multivariable analyses were: R1\/2 resection (hazard ratio 9.30; 95% confidence interval 1.82\u201336.1), TEN subtype (hazard ratio 8.08; 95% confidence interval 1.24\u201334.6), and presence of lymphovascular invasion (hazard ratio 9.56; 95% confidence interval 2.56\u201325.8).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Complete resection remains critical in patients with TEN. Incomplete resection, high-risk histology, and lymphovascular invasion highlight the need for effective adjuvant modalities. Given the rarity of these diseases, emphasis must be placed on collaborative research conducted on TEN.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac274","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T19:13:55Z","timestamp":1650568435000},"source":"Crossref","is-referenced-by-count":12,"title":["Factors predicting recurrence in thymic epithelial neoplasms"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-5468","authenticated-orcid":false,"given":"Aroub","family":"Alkaaki","sequence":"first","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Abo Al-Saud","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2339-3778","authenticated-orcid":false,"given":"\u00c9lise","family":"Di Lena","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Ramirez-GarciaLuna","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Najmeh","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Spicer","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ferri","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mulder","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sirois","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-6889","authenticated-orcid":false,"given":"Jonathan","family":"Cools-Lartigue","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Upper Gastrointestinal Surgery, McGill University , Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"2022102811594903500_ezac274-B1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ijc.11099","article-title":"Malignant thymoma in the United States: demographic patterns in incidence and associations with subsequent malignancies","volume":"105","author":"Engels","year":"2003","journal-title":"Int J Cancer"},{"key":"2022102811594903500_ezac274-B2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1097\/JTO.0000000000000654","article-title":"The 2015 World Health Organization classification of tumors of the thymus: continuity and changes","volume":"10","author":"Marx","year":"2015","journal-title":"J Thorac Oncol"},{"key":"2022102811594903500_ezac274-B3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/ejcts\/ezt649","article-title":"Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database","volume":"46","author":"Ruffini","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"2022102811594903500_ezac274-B4","doi-asserted-by":"crossref","first-page":"v40","DOI":"10.1093\/annonc\/mdv277","article-title":"Thymic epithelial tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"26(Suppl 5)","author":"Girard","year":"2015","journal-title":"Ann Oncol"},{"key":"2022102811594903500_ezac274-B5","author":"NCCN Clinical Practice Guidelines in 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