{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:53:01Z","timestamp":1787313181990,"version":"build-2736575974"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Extensive infective endocarditis (IE) stays a serious life-threatening disease with high mortality and morbidity. The aim of this study is to analyse our experience with our modified surgical technique for extensive IE during the last 4\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Between March 2017 and February 2021, all patients with extensive IE required our modified technique consisting of a radical surgical resection of all infected cardiac tissues, the replacement of infected valves and a reconstruction of the intervalvular fibrous body, the aortic root and the left ventricular outflow tract with modified elephant trunk were included in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Our modified technique was performed on 41 patients during the study period. The age median was 74 [interquartile range (IQR): 66.5\u201376.5] and 61.0% (n\u2009=\u200925) were female. Thirty-three patients (80.5%) were in New York Heart Association Class III\u2013IV and 7 patients (17.1%) in cardiogenic shock. The median logistic European system for cardiac operative risk evaluation II as predicted risk of mortality was 35% (IQR: 28\u201378%). The median cardiopulmonary bypass time and cross-clamping time were 126 (IQR: 86.5\u2013191) and 78 (IQR: 55.5\u2013108) min, respectively. Intraoperative mortality and 30-day mortality were 4.8% (2 patients) and 19.5% (8 patients), respectively. Low cardiac output with necessity for mechanical support, stroke and new renal dialysis developed in 9.8% (4 patients), 17.1% (7 patients) and 22.0% (9 patients), respectively. New pacemaker implantation was noted in 39.0% (16 patients). Intensive care stay and hospital stay had medians of 6 (IQR: 5\u201312) and 14 (IQR: 12.5\u201320.5) days, respectively. One-year mortality and 4-year mortality were 34.1% (14 patients) and 39.0% (16 patients), respectively. Kaplan\u2013Meier survival estimates were 60.3% (95% confidence interval: 46.2\u201378.6%) at 3\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Our modified technique can be performed in patients with extensive IE with acceptable early and mid-term morbidity and mortality. We believe that this technique is an available option for this ill-fated group of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac311","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T08:18:44Z","timestamp":1652948324000},"source":"Crossref","is-referenced-by-count":5,"title":["Modification of reconstruction of left ventricular outflow tract, aortic root and the intervalvular fibrous body for extensive infective endocarditis: a single-centre experience"],"prefix":"10.1093","volume":"62","author":[{"given":"Ali","family":"El-Sayed Ahmad","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, Heart Centre Siegburg-Wuppertal, University Witten-Herdecke , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Salamate","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Heart Centre Siegburg-Wuppertal, University Witten-Herdecke , 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