{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:23:21Z","timestamp":1792686201501,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>This analysis evaluated the safety, durability and haemodynamic performance of a stented bovine pericardial valve through 5\u2009years of follow-up in patients with an indication for surgical aortic valve replacement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Kaplan\u2013Meier analysis was used to estimate the incidence of survival and valve-related thromboembolism, major paravalvular leak, endocarditis, structural valve deterioration (SVD) and reintervention. The mean aortic gradient and New York Heart Association (NYHA) functional class were also evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 1118 patients have received the Avalus valve; 564 have completed the 5-year follow-up. The median follow-up was 4.85\u2009years (4810 patient-years total follow-up). At baseline, the mean age was 70.2\u2009\u00b1\u20099.0\u2009years; 75.1% of patients were male. The Society of Thoracic Surgeons predicted risk of mortality was 2.0\u2009\u00b1\u20091.4%. Most patients were in NYHA functional class II (46.8%) or III (40.3%). At the 5-year follow-up, the overall Kaplan\u2013Meier survival rate was 88.1% (85.9\u201390.0%). The Kaplan\u2013Meier event rates were 5.6% (4.3\u20137.2%) for thromboembolism, 4.4% (3.2\u20136.0%) for endocarditis, 0.2% (0.0\u20130.7%) for a major paravalvular leak and 3.2% (2.3\u20134.6%) for reintervention. There were no cases of SVD. The mean gradient decreased from 42.1\u2009\u00b1\u200917.1\u2009mmHg at baseline, to 13.1\u2009\u00b1\u20094.7\u2009mmHg at discharge and remained stable at 12.5\u2009\u00b1\u20094.6\u2009mmHg at 5\u2009years. More than 95% of patients were in NYHA functional class I\/II 5\u2009years after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The findings of a high survival rate, excellent safety, no SVD and stable haemodynamic performance and functional status through 5\u2009years of follow-up are encouraging. Additional follow-up is needed to assess the long-term durability of this contemporary surgical bioprosthesis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac374","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T13:47:31Z","timestamp":1657028851000},"source":"Crossref","is-referenced-by-count":26,"title":["Surgical aortic valve replacement with a stented pericardial bioprosthesis: 5-year outcomes"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6507-3855","authenticated-orcid":false,"given":"Robert J M","family":"Klautz","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Leiden University Medical Center , Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Dagenais","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Quebec Heart and Lung Institute , Quebec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Reardon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Houston Methodist DeBakey Heart and Vascular Center , Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich , Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G","family":"Moront","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, ProMedica Toledo Hospital , Toledo, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8542-9049","authenticated-orcid":false,"given":"Louis","family":"Labrousse","sequence":"additional","affiliation":[{"name":"Medico-Surgical Department of Valvulopathies, Bordeaux Heart University Hospital , Bordeaux-Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J","family":"Weissman","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute, MedStar Health , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-0937","authenticated-orcid":false,"given":"Vivek","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Surgery, Toronto General Hospital , Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-2416","authenticated-orcid":false,"given":"Himanshu J","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Frankel Cardiovascular Center, University of Michigan , Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Clinical Research and Medical Science , Medtronic, Mounds View , MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Joseph F","family":"Sabik","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine , Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"2022080307192919500_ezac374-B1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","article-title":"Surgical or transcatheter aortic-valve replacement in intermediate-risk patients","volume":"376","author":"Reardon","year":"2017","journal-title":"N Engl J 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