{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:12:52Z","timestamp":1793445172569,"version":"4.5.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The objective was to analyse associations between obesity and outcomes after left ventricular assist device (LVAD) implantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A retrospective analysis of the EUROMACS Registry was performed. Adult patients undergoing primary implantation of a continuous-flow LVAD between 2006 and 2019 were included (Medtronic HeartWare\u00ae HVAD\u00ae, Abbott HeartMate II\u00ae, Abbott HeartMate 3\u2122). Patients were classified into 4 different groups according to body mass index at the time of surgery (body mass index &amp;lt;20\u2009kg\/m2: n\u2009=\u2009254; 20\u201324.9\u2009kg\/m2: n\u2009=\u20091281; 25\u201329.9\u2009kg\/m2: n\u2009=\u20091238; \u2265 30\u2009kg\/m2: n\u2009=\u2009691).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The study cohort was comprised of 3464 patients. Multivariable Cox proportional cause-specific hazards regression analysis demonstrated that obesity (body mass index \u226530\u2009kg\/m2) was independently associated with significantly increased risk of mortality (body mass index \u226530 vs 20\u201324.9 kg\/m2: hazard ratio 1.36, 95% confidence interval 1.18\u20131.57, overall P\u2009&amp;lt;\u20090.001). Moreover, obesity was associated with significantly increased risk of infection and driveline infection. The probability to undergo heart transplantation was significantly decreased in obese patients (body mass index \u226530 vs 20\u201324.9 kg\/m2: hazard ratio 0.59, 95% confidence interval 0.48\u20130.74, overall P\u2009&amp;lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Obesity at the time of LVAD implantation is associated with significantly higher mortality and increased risk of infection as well as driveline infection. The probability to undergo heart transplantation is significantly decreased. These aspects should be considered when devising a treatment strategy before surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac401","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T13:23:47Z","timestamp":1658928227000},"source":"Crossref","is-referenced-by-count":15,"title":["Obesity and outcomes after left ventricular assist device implantation: insights from the EUROMACS Registry"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8378-0633","authenticated-orcid":false,"given":"Philipp","family":"Angleitner","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kaider","sequence":"additional","affiliation":[{"name":"Center for Medical Statistics, Informatics, and Intelligent Systems (CeMSIIS), Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo M M H","family":"De By","sequence":"additional","affiliation":[{"name":"EUROMACS Registry, EACTS House , Windsor, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5887-294X","authenticated-orcid":false,"given":"Kamen","family":"Dimitrov","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-4860","authenticated-orcid":false,"given":"Thomas","family":"Schl\u00f6glhofer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens F","family":"Tops","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , 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