{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:26:48Z","timestamp":1792794408161,"version":"4.5.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"German Cardiac Society, German Society for Thoracic and Cardiovascular Surgery and German Heart Foundation","id":[{"id":"https:\/\/ror.org\/049xawg80","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Aortic valve (AV) repair is an evolving surgical strategy in the treatment of young patients with aortic regurgitation (AR) and\/or aortic root aneurysm. We aimed to determine the clinical outcome following AV repair\/AV-sparing root surgery using real-world data from the German Aortic Valve Registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 2327 patients with AR (mean age 55.2\u2009\u00b1\u200915.0\u2009years, 76% men), who underwent AV repair\/AV-sparing root surgery between 2011 and 2015 (i.e. 5% of 42\u00a0868 AV surgery patients enrolled in the German Aortic Valve Registry during the same period) were included. Study cohort was subdivided according to the technique of AV repair: isolated AV repair without root surgery (group I) (n\u2009=\u2009914), AV-sparing root surgery (i.e. reimplantation or remodelling) without cusp repair (group II) (n\u2009=\u20091077) and AV-sparing root surgery (i.e. reimplantation or remodelling) with simultaneous cusp repair (group III) (n\u2009=\u2009336). Primary end point was 1-year survival after AV repair\/AV-sparing root surgery. Secondary end points were freedom from cardiac adverse events and freedom from AV reinterventions at 1-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Thirty-day mortality was 19 (0.8%) in the whole study cohort without significant differences in the 3 subgroups [4 (0.4%) patients in group I vs 14 (1.3%) patients in group II vs 1 (0.3%) patient in group III (P\u2009=\u20090.054)]. Postoperatively, 1445 (74%) patients had no residual AR, 474 (24%) patients had mild AR and 40 (2%) patients had moderate\/severe AR at the time of hospital discharge. One-year survival (95% confidence interval) was 97.7% (97.1\u201398.3) in the whole study cohort and without significant difference among the 3 subgroups. One-year cardiac adverse event-free survival (95% confidence interval) was 85.7% (84.2\u201387.1) and was similar in all 3 study groups in propensity score-weighted analysis. A total of 38 (1.6%) patients required AV reintervention during a 1-year follow-up, without significant difference among subgroups (P\u2009=\u20090.11).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>AV repair\/AV-sparing root surgery is performed in 5% of patients requiring AV surgery in Germany. Our data demonstrate very satisfactory periprocedural and 1-year survival and cardiac event-free survival after AV repair surgery. Implementation of specific surgical techniques during the index procedure seems to result in comparable outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac416","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T07:07:18Z","timestamp":1660374438000},"source":"Crossref","is-referenced-by-count":11,"title":["Outcomes of aortic valve repair: early results from the German Aortic Valve Registry"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-4244","authenticated-orcid":false,"given":"Evaldas","family":"Girdauskas","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center, University Medical Center Hamburg-Eppendorf , Hamburg, Germany"},{"name":"Department of Cardiothoracic Surgery, Augsburg University Hospital , Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-3385","authenticated-orcid":false,"given":"Johannes","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart & Vascular Center, University Medical Center Hamburg-Eppendorf , Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcmniye","family":"Balaban","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Mathematical Modelling, Goethe University , Frankfurt, Germany"},{"name":"German Center for Cardiovascular Research, DZHK, Partner Site Rhine-Main , Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0662-6675","authenticated-orcid":false,"given":"Eva","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Mathematical Modelling, Goethe University , Frankfurt, Germany"},{"name":"German Center for Cardiovascular Research, DZHK, Partner Site Rhine-Main , Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Bauer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Department of Cardiology, University of Giessen , Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Beckmann","sequence":"additional","affiliation":[{"name":"German Society for Thoracic and Cardiovascular Surgery, Langenbeck-Virchow-Haus , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffi","family":"Bekeredjian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Robert-Bosch Hospital , Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-3261","authenticated-orcid":false,"given":"Stephan","family":"Ensminger","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Medical Center Schleswig-Holstein , L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Frerker","sequence":"additional","affiliation":[{"name":"II. 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