{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:04:27Z","timestamp":1767859467623,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972168"],"award-info":[{"award-number":["81972168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Development Fund of Zhongshan Hospital, Fudan University","award":["2020ZSCX11"],"award-info":[{"award-number":["2020ZSCX11"]}]},{"name":"Research Development Fund of Zhongshan Hospital, Fudan University","award":["2021ZSYQ28"],"award-info":[{"award-number":["2021ZSYQ28"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>We recently reported a high rate of nontherapeutic thymectomy. Mediastinal lymphomas (MLs) are the malignancies most likely to be confused with thymic epithelial tumours (TETs). This study aimed to establish a predictive model by evaluating clinical variables and positron emission tomography to distinguish those diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>From 2018 to 2021, consecutive patients who were pathologically diagnosed with TETs or MLs were retrospectively reviewed. Univariable and multivariable analyses were used to identify association factors. The Akaike information criterion was used to select variables. A nomogram was developed and validated to differentiate MLs from TETs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 198 patients were included. Compared with TETs, patients with MLs were more likely to be younger with higher metabolic tumour volume (154.1 vs 74.6\u2009cm3), total lesion glycolysis (1388.8 vs 315.2\u2009g\/ml cm3), SUVmean (9.2 vs 4.8), SUVpeak (12.9 vs 6.3) and SUVmax (14.8 vs 7.5). A nomogram was established based on the stepwise regression results and the final model containing age and SUVmax had minimal Akaike information criterion value of 72.28. Receiver operating characteristic analyses indicated that the area under the curve of predictive nomogram in differentiating MLs from TETs was 0.842 (95% CI: 0.754\u20130.907). The internal bootstrap resampling and calibration plots demonstrated good consistence between the prediction and the observation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Combination of age and SUVmax appears to be a useful tool to differentiate MLs from TETs. The novel predictive model prevents more patients from receiving nontherapeutic thymectomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac459","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T16:15:58Z","timestamp":1664295358000},"source":"Crossref","is-referenced-by-count":5,"title":["A novel predictive model for distinguishing mediastinal lymphomas from thymic epithelial tumours"],"prefix":"10.1093","volume":"62","author":[{"given":"Shuai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch) , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Zhongshan Hospital, Fudan University; Institute of Nuclear Medicine, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Ao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongcheng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Zhongshan Hospital, Fudan University; Institute of Nuclear Medicine, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luya","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"2022112312291740600_ezac459-B1","doi-asserted-by":"crossref","DOI":"10.1093\/icvts\/ivac132","article-title":"How can the rate of nontherapeutic thymectomy be reduced?","volume":"35","author":"Wang","year":"2022","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2022112312291740600_ezac459-B2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1148\/rg.2017160095","article-title":"ITMIG classification of mediastinal compartments and multidisciplinary approach to mediastinal masses","volume":"37","author":"Carter","year":"2017","journal-title":"Radiographics"},{"key":"2022112312291740600_ezac459-B3","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1097\/JTO.0000000000000294","article-title":"Approaching the patient with an anterior mediastinal mass: a guide for clinicians","volume":"9","author":"Carter","year":"2014","journal-title":"J Thorac Oncol"},{"key":"2022112312291740600_ezac459-B4","volume-title":"NCCN Guidelines: Thymomas and Thymic Carcinomas 1.2020","author":"Ettinger","year":"2019"},{"key":"2022112312291740600_ezac459-B5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/RTI.0b013e31828609a0","article-title":"Advances in thymoma imaging","volume":"28","author":"Marom","year":"2013","journal-title":"J Thorac Imaging"},{"key":"2022112312291740600_ezac459-B6","doi-asserted-by":"crossref","first-page":"S1717","DOI":"10.1097\/JTO.0b013e31821e8cd6","article-title":"Standard report terms for chest computed tomography reports of anterior mediastinal masses suspicious for thymoma","volume":"6","author":"Marom","year":"2011","journal-title":"J Thorac Oncol"},{"key":"2022112312291740600_ezac459-B7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ejrad.2014.11.042","article-title":"High rate of unnecessary thymectomy and its cause. 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