{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T12:28:01Z","timestamp":1775824081727,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Clinical outcomes of 2 generations of pericardial bioprostheses in concomitant aortic valve and coronary artery bypass graft surgery were analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Patients were recruited from 2 European centres and divided into 2 groups based on the type of aortic bioprosthesis used: Edwards Intuity Elite\u2122 rapid-deployment (RD) bioprostheses or standard Edwards Magna Ease (ME). A propensity score weighting approach was used for data analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 285 patients were included: 144 (50.5%) in the RD group and 141 (49.5%) in the ME group. Thirty-day mortality was 2.8% (RD) and 5% (ME) (P\u2009=\u20090.09). Significantly shorter times of aortic cross-clamp and cardiopulmonary bypass were observed in the RD cohort [94 vs 120\u2009min (P\u2009&amp;lt;\u20090.001); 128 vs 160\u2009min (P\u2009&amp;lt;\u20090.001)]. The RD group was associated with a lower median transvalvular gradient at discharge and follow-up (both P\u2009&amp;lt;\u20090.001). However, 5-year survival was not different, being 93% in RD patients and 91% in the ME group [hazard ratio 0.89 (95% confidence interval: 0.38\u20132.09), P\u2009=\u20090.784]. The 5-year cumulative incidence of combined events (including percutaneous coronary interventions, endocarditis, thromboembolic events, rehospitalizations and bleeding) favoured the ME group [16.1% (RD) vs 7.3% (ME)] [hazard ratio 2.38 (95% confidence interval:1.03\u20135.52), P\u2009=\u20090.043]. However, this turned similar when the Cox model analysis was adjusted for revascularization variables (P\u2009=\u20090.067).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>RD and ME pericardial bioprostheses used in concomitant aortic valve replacement and coronary artery revascularization provide equivalent clinical and haemodynamic 5-year outcomes, despite constant lower transvalvular gradients and shorter surgical operating times observed with RD technology.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac476","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T20:50:44Z","timestamp":1664571044000},"source":"Crossref","is-referenced-by-count":5,"title":["Standard versus rapid-deployment aortic valve replacement and concomitant myocardial revascularization: 5-year bi-centre clinical outcomes"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-2983","authenticated-orcid":false,"given":"Tomaso","family":"Bottio","sequence":"first","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-8586","authenticated-orcid":false,"given":"Antonio","family":"Piperata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvise","family":"Guariento","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Lorenzoni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Gualtiero","family":"Cavicchiolo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gemelli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Michelotti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Gastino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of Padua , Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Gregori","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoracic, Vascular, and Public Health Sciences, University of 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