{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:52:27Z","timestamp":1753876347714,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The residual thoracic spaces (RTS) after pleurectomy\/decortication (P\/D) remain unexplored to date. Hence, this study aims to examine the details and risk factors of RTS during the 3 post-P\/D months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We retrospectively examined patients who underwent neoadjuvant chemotherapy, followed by P\/D for malignant pleural mesothelioma from September 2012 to December 2020. The RTS group included cases of residual thoracic cavity unaccompanied by pleural effusion on 3 postoperative months computed tomography. We determined risk factors for RTS using univariable and multivariable analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of 170 patients examined, 58 (34.1%) were in the RTS group and 112 (65.9%) in the non-RTS group. In the RTS group, 43 patients recovered from RTS during the follow-up period; 4 patients developed chronic fistular empyema, while 2 required fenestration and 2 were thoracoscopic debridement. Besides, 11 patients exhibited RTS continuously. The univariable analysis revealed that compared with the non-RTS group, the RTS group reported a significantly longer postoperative air leak (&amp;gt;7\u2009days; P &amp;lt; 0.01) and right P\/D (P = 0.04). The multivariable analysis demonstrated that longer postoperative air leak (&amp;gt;7\u2009days) remained a risk factor for RTS (odds ratio 2.5, 95% confidence interval: 1.3\u20134.9, P &amp;lt; 0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>RTS was a postoperative event that frequently observed in patients undergoing P\/D. Overall, the current study findings suggest longer postoperative air leak (&amp;gt;7\u2009days) as a significant risk factor for RTS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac500","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T14:44:04Z","timestamp":1666190644000},"source":"Crossref","is-referenced-by-count":7,"title":["Long-term outcomes and risk factors of residual thoracic spaces after pleurectomy\/decortication for mesothelioma"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-9527","authenticated-orcid":false,"given":"Akifumi","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Hyogo College of Medicine , Nishinomiya, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department 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