{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:22:30Z","timestamp":1762161750183,"version":"3.41.2"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Shanghai Municipal Science and Technology Commission Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p\/><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Anomalous left coronary artery from the pulmonary artery (ALCAPA) is frequently associated with significant mitral regurgitation (MR). We aim to identify surgical outcomes in patients with or without concomitant mitral intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>All patients with ALCAPA who presented with &amp;gt;mild degree of MR at our institution between January 2008 and June 2020 were included in the retrospective study. MR recovery was defined as \u2264mild MR at the last follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The study cohort included 101 patients. The median age at repair was 7.6\u2009months. The concomitant mitral intervention was performed in 66 patients (65%). MR grade significantly improved at the last follow-up. The cumulative incidence of MR recovery 3\u2009years after ALCAPA repair was 34% [95% confidence interval (CI), 19\u201350%) in patients with mitral intervention, compared to 59% (95% CI, 41\u201373%) in patients without mitral intervention (P\u2009=\u20090.050). MR grade on postoperative day 1 was the predictor for MR recovery in patients with mitral intervention (hazard ratio, 0.080; 95% CI, 0.018\u20130.366; P\u2009=\u20090.001), whereas preoperative mitral annulus diameter z-score was the predictor in patients without mitral intervention (hazard ratio, 0.480; 95% CI, 0.232\u20130.993; P\u2009=\u20090.048). Freedom from mitral reoperation in patients with mitral intervention was 94% and 88% at 3 and 5\u2009years after surgery, while freedom from mitral reoperation in patients without mitral intervention was 100% at both timepoints (P\u2009=\u20090.177).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Despite significant MR improvement after ALCAPA repair, MR grade may not always return to normal regardless of the initial mitral management strategy, and reoperation for persistent MR is not rare.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejcts\/ezac521","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T15:52:42Z","timestamp":1667404362000},"source":"Crossref","is-referenced-by-count":2,"title":["Mitral intervention for anomalous left coronary artery from the pulmonary artery: midterm outcomes"],"prefix":"10.1093","volume":"63","author":[{"given":"Wen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Shanghai Children\u2019s Medical Center, Shanghai Jiaotong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renjie","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Shanghai Children\u2019s Medical Center, Shanghai Jiaotong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Shanghai Children\u2019s Medical Center, Shanghai Jiaotong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Shanghai Children\u2019s Medical Center, Shanghai Jiaotong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Shanghai Children\u2019s Medical Center, Shanghai Jiaotong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Shanghai Children\u2019s Medical Center, Shanghai Jiaotong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-8842","authenticated-orcid":false,"given":"Haibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Shanghai Children\u2019s Medical Center, Shanghai Jiaotong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"2023022120293982100_","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1017\/S1047951115002565","article-title":"Echocardiographic presentation of anomalous origin of the left coronary artery from the pulmonary artery","volume":"25","author":"Silverman","year":"2015","journal-title":"Cardiol Young"},{"key":"2023022120293982100_","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jtcvs.2019.09.179","article-title":"Surgical outcomes for anomalous left coronary artery from the pulmonary artery: influence of late presentation","volume":"159","author":"Zhang","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023022120293982100_","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1067\/mtc.2001.112834","article-title":"Surgical intervention for anomalous origin of the left coronary artery from the 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anomalous left coronary artery from the pulmonary artery repair: a 40-year single-centre experience","volume":"53","author":"Lange","year":"2018","journal-title":"Eur J Cardiothorac Surg"},{"key":"2023022120293982100_","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1053\/j.semtcvs.2020.01.005","article-title":"Mitral valve surgery in neonates, infants and children: surgical approach, outcomes, & predictors","volume":"32","author":"Isaacson","year":"2020","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"2023022120293982100_","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/ejcts\/ezx074","article-title":"Technical performance scores are predictors of midterm mortality and reinterventions following congenital mitral valve repair","volume":"52","author":"Martin","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2023022120293982100_","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/echo.14788","article-title":"Unexpected 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