{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:43:40Z","timestamp":1787496220625,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>A conclusive interpretation of the role of ventricular dominance in outcomes after Fontan palliation has not been formulated yet. We conducted a systematic review and meta-analysis of scientific literature to give an insight into the impact of ventricular morphology in single-ventricle palliation, focusing on its influence on survival, morbidities, ventricular performance and functional capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A systematic review of PubMed, Web of Science and Scopus databases was performed. A random-effect meta-analysis was conducted, and survival data were reconstructed using the published Kaplan\u2013Meier survival curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Twenty-seven studies were selected, for a total of 4529 left-dominant versus 4844 right-dominant patients. Estimated survival at 1, 5, 10, 20 and 30\u2009years of follow-up was 0.99 [95% confidence interval (CI)\u2009=\u20090.98\u20130.99], 0.95 [95% CI\u2009=\u20090.94\u20130.96], 0.92 [95% CI\u2009=\u20090.91\u20130.93], 0.86 [95% CI\u2009=\u20090.84\u20130.88] and 0.68 [95% CI\u2009=\u20090.65\u20130.83] for left-dominant patients and 0.94 [95% CI\u2009=\u20090.93\u20130.95], 0.89 [95% CI\u2009=\u20090.88\u20130.9], 0.85 [95% CI\u2009=\u20090.83\u20130.87], 0.69 [95% CI\u2009=\u20090.63\u20130.75] and 0.59 [95% CI\u2009=\u20090.5\u20130.69] for right-dominant patients, respectively. Survival was statistically lower for right-dominant patients (P\u2009&amp;lt;\u20090.001), with an hazard ratio for the mortality of 2.38 (2.03\u20132.80); also, they displayed significantly longer hospital stay, worse ventricular function, larger ventricular volumes and a higher incidence of moderate or severe atrioventricular valve regurgitation when compared to left-dominant patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>According to our meta-analysis, the morphology of the dominant ventricle has a significant impact on outcomes after Fontan palliation. Right-dominant patients experience an inferior long-term survival when the anatomical right ventricle is included in the systemic circulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac535","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T07:19:25Z","timestamp":1668151165000},"source":"Crossref","is-referenced-by-count":38,"title":["Ventricular morphology of single-ventricle hearts has a significant impact on outcomes after Fontan palliation: a meta-analysis"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-6287","authenticated-orcid":false,"given":"Matteo","family":"Ponzoni","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, Pediatric and Congenital Cardiac Surgery Unit, University of Padova Medical School, Padova , 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Salvo","sequence":"additional","affiliation":[{"name":"Department of Woman and Child's health, Pediatric Cardiology Unit, University of Padova Medical School, Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"D\u2019Udekem","sequence":"additional","affiliation":[{"name":"Children\u2019s National Hospital, The George Washington University School of Medicine and Health Sciences , Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-0259","authenticated-orcid":false,"given":"Vladimiro","family":"Vida","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, Pediatric and Congenital Cardiac Surgery Unit, University of Padova Medical School, Padova , 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