{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:09:49Z","timestamp":1793498989772,"version":"4.5.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Endospan Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Endovascular aortic arch stent grafting with branched devices has shown initial promising results. The aim of this prospective, multicentre study was to evaluate 3-year outcomes of aortic arch stent grafting with NEXUS\u00ae Aortic Arch Stent Graft System (Nexus), a single-branch, bi-modular, off-the-shelf aortic arch stent graft system in high-risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Patients treated with Nexus, either under the feasibility clinical study or as compassionate use procedures in 5 centres, were included in this study. The primary end point was overall survival. The secondary end points included the incidence of procedure-related unplanned intervention, stroke, paraplegia and endoleak. Clinical and radiologic follow-up was performed at each study site at 30\u2009days, 6\u2009months and on a yearly basis thereafter up to 3\u2009years postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We analysed data from a total of 28 patients. The overall median follow-up was 1132 (interquartile range: 809\u20131537). There were no device or procedure-related deaths between 1 and 3 years. Overall survival at 1 and 3 years was 89% and 71%, respectively. The cumulative incidence of unplanned reintervention at 1 and 3 years was 11% and 29%, respectively. There were no reports of stroke, paraplegia, aneurysm rupture, myocardial infarction or new aortic valve insufficiency. In this study\u2019s 1\u20133\u2009year follow-up period, 1 type Ib (4%), 1 type II (4%) and 2 type III (8%; between Nexus\u2019 distal end and Thoracic endovascular aortic repair (TEVAR) extensions) endoleak were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Endovascular aortic arch exclusion with the single-branch, off-the-shelf Nexus system provides promising clinical and radiologic results at 3-year follow-up in a high-risk patient cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac561","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T09:36:25Z","timestamp":1670578585000},"source":"Crossref","is-referenced-by-count":25,"title":["Three-year follow-up of aortic arch endovascular stent grafting with the Nexus device: results from a prospective multicentre study"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-9091","authenticated-orcid":false,"given":"Augusto","family":"D\u2019Onofrio","sequence":"first","affiliation":[{"name":"University of Padova, Department of Cardiac, Thoracic, Vascular Surgery and Public Health , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Lachat","sequence":"additional","affiliation":[{"name":"Clinic Hirslanden, Aortic and Vascular Center , Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Mangialardi","sequence":"additional","affiliation":[{"name":"Ospedale San Camillo-Forlanini, Department of Vascular Surgery , Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Antonello","sequence":"additional","affiliation":[{"name":"University of Padova, Department of Cardiac, Thoracic, Vascular Surgery and Public Health , Padova, 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