{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:24:17Z","timestamp":1792815857913,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Pathological lymph node metastases are often observed in patients with clinical N0 lung cancer. Identifying preoperative predictors of occult hilar nodal metastasis (OHNM) is important in determining the surgical procedure in patients with clinical stage I non-small-cell lung cancer. This study aimed to determine the frequency and predictors of OHNM by tumour location in these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Between April 2007 and May 2019, data of patients who underwent lobectomy or segmentectomy for clinical stage I pure-solid non-small-cell lung cancer were retrospectively reviewed. The ratio of the distance from the pulmonary hilum to the proximal side of the tumour to the distance from the pulmonary hilum to the visceral pleural surface through the centre of the tumour, named \u2018distance ratio (DR)\u2019, was calculated. The relationship of the DR with clinicopathological findings and prognosis was discussed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 357 patients were enrolled. OHNM frequency was 14.6%. Patients were divided into 2 groups based on whether the DR was \u22640.67 (central type) or &amp;gt;0.67 (peripheral type). The frequency of OHNM was significantly higher in the DR \u22640.67 group (21.5% vs 7.4%; P\u2009&amp;lt;\u20090.001). Multivariable analysis revealed that DR was the only independent preoperative predictor of OHNM (odds ratio, 3.63; 95% confidence interval, 1.83\u20137.18; P\u2009&amp;lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The frequency of OHNM was significantly lower in peripheral-type lung cancer; therefore, tumour location was the most important preoperative predictor of OHNM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac575","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T14:21:38Z","timestamp":1672064498000},"source":"Crossref","is-referenced-by-count":35,"title":["Tumour location predicts occult N1 nodal metastasis in clinical stage I non-small-cell lung cancer"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-0894","authenticated-orcid":false,"given":"Nobutaka","family":"Kawamoto","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University , Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-1027","authenticated-orcid":false,"given":"Yasuhiro","family":"Tsutani","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University , Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-2443","authenticated-orcid":false,"given":"Atsushi","family":"Kamigaichi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University , Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manato","family":"Ohsawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University , Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-8928","authenticated-orcid":false,"given":"Takahiro","family":"Mimae","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University , Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University , Hiroshima, 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