{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:42:04Z","timestamp":1791549724423,"version":"4.3.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to describe the epidemiology of patients undergoing diagnostic and\/or curative surgical pulmonary resections for lung opacities suspected of being localized primary lung cancers without preoperative tissue confirmation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We performed a single-centre retrospective study of a prospectively implemented institutional database of all patients who underwent pulmonary resection between January 2010 and December 2020. Patients were selected when surgery complied with the Fleischner society guidelines. We performed a multivariable logistic regression to determine the preoperative variables associated with malignancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Among 1392 patients, 213 (15.3%) had a final diagnosis of benignancy. We quantified futile parenchymal resections in 29 (2.1%) patients defined by an anatomical resection of &amp;gt;2 lung segments for benign lesions that did not modified the clinical management. Compared with patients with malignancies, patients with benignancies were younger (57.5 vs 63.9 years, P\u2009&amp;lt;\u20090.001), had lower preoperative risk profile (thoracoscore 0.4 vs 2.1, P\u2009&amp;lt;\u20090.001), had a higher proportion of wedge resection (50.7% vs 12.2%, P\u2009&amp;lt;\u20090.01) and experienced a lower burden of postoperative complication (Clavien\u2013Dindo IV or V, 0.4% vs 5.6%, P\u2009&amp;lt;\u20090.001). Preoperative independent variables associated with malignancy were (adjusted odd ratio [95% confident interval]) age 1.02 [1.00; 1.04], smoking (year-pack) 1.005 (1.00; 1.01), history of cardiovascular disease 2.06 [1.30; 3.30], history of controlled cancer 2.74 [1.30; 6.88] and clinical N involvement 4.20 [1.11; 37.44].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Futile parenchymal lung resection for suspicious opacities without preoperative tissue diagnosis is rare (2.1%) while surgery for benign lesions represented 15.3% and has a satisfactory safety profile with very low postoperative morbi-mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezac590","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T03:22:35Z","timestamp":1673148155000},"source":"Crossref","is-referenced-by-count":11,"title":["Benignant and malignant epidemiology among surgical resections for suspicious solitary lung cancer without preoperative tissue diagnosis"],"prefix":"10.1093","volume":"63","author":[{"given":"Elsa","family":"Armand","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Lung Transplantation and Esophageal Diseases, H\u00f4pital Nord , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-4565","authenticated-orcid":false,"given":"David","family":"Boulate","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Lung Transplantation and Esophageal Diseases, H\u00f4pital Nord , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Fourdrain","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Lung Transplantation and Esophageal Diseases, H\u00f4pital Nord , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc-Anh-Thu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Economics, APHM , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Resseguier","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Economics, APHM , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Brioude","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Lung Transplantation and Esophageal Diseases, H\u00f4pital Nord , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Trousse","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Lung Transplantation and Esophageal Diseases, H\u00f4pital Nord , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Doddoli","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Lung Transplantation and Esophageal Diseases, H\u00f4pital Nord , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier-Benoit","family":"D\u2019journo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Lung Transplantation and Esophageal Diseases, H\u00f4pital Nord , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3305-6989","authenticated-orcid":false,"given":"Pascal-Alexandre","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Lung Transplantation and Esophageal Diseases, H\u00f4pital Nord , Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"2023010913455236000_ezac590-B1","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1164\/rccm.201505-0990OC","article-title":"Recent trends in the identification of incidental pulmonary nodules","volume":"192","author":"Gould","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2023010913455236000_ezac590-B2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1148\/radiol.2017161659","article-title":"Guidelines for management of incidental pulmonary nodules detected on CT images: from the Fleischner Society 2017","volume":"284","author":"MacMahon","year":"2017","journal-title":"Radiology"},{"key":"2023010913455236000_ezac590-B3","doi-asserted-by":"crossref","first-page":"e93S","DOI":"10.1378\/chest.12-2351","article-title":"Evaluation of individuals with pulmonary nodules: when is it lung cancer? 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