{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:38:48Z","timestamp":1793813928701,"version":"4.6.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100018234","name":"Bern University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018234","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Neuroprotection during aortic arch surgery involves selective antegrade cerebral perfusion. The parameters of cerebral perfusion, e.g. flow rate, are inconsistent across centres and are subject of debate. The aim of this study was to determine the cerebral perfusion flow rate during hypothermic circulatory arrest required to meet preoperative awake baseline regional cerebral oxygen saturation (rSO2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Patients scheduled for aortic arch surgery with hypothermic circulatory arrest were enrolled in this prospective observational study. After initiation of hypothermic circulatory arrest, bilateral selective antegrade cerebral perfusion was established and cerebral flow rate was continuously increased. The primary end point was the difference of cerebral saturation from baseline during cerebral perfusion flow rates of 6, 8 and 10\u2009ml\/kg\/min.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 40 patients were included. During antegrade cerebral perfusion, rSO2 was significantly lower than the baseline at 6\u2009ml\/kg\/min [\u22127.3, 95% confidence interval (CI): \u22121.7, \u221212.9; P\u2009=\u20090.0015]. In contrast, flow rates of 8 and 10\u2009ml\/kg\/min resulted in rSO2 that did not significantly differ from the baseline (\u22122; 95% CI: \u22124.3, 8.3; P\u2009&amp;gt;\u20090.99 and 1.8; 95% CI: \u22128.5%, 4.8%; P\u2009&amp;gt;\u20090.99). Cerebral saturation was significantly more likely to meet baseline values during selective antegrade cerebral perfusion with 8\u2009ml\/kg\/min than at 6\u2009ml\/kg\/min (44.1%; 95% CI: 27.4%, 60.8% vs 11.8%; 95% CI: 0.9%, 22.6%; P\u2009=\u20090.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>At 8\u2009ml\/kg\/min cerebral flow rate during selective antegrade cerebral perfusion, regional cerebral oximetry baseline values are significantly more likely to be achieved than at 6\u2009ml\/kg\/min. Further increasing the cerebral flow rate to 10\u2009ml\/kg\/min does not significantly improve rSO2.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad047","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T15:35:08Z","timestamp":1676043308000},"source":"Crossref","is-referenced-by-count":19,"title":["Determination of selective antegrade perfusion flow rate in aortic arch surgery to restore baseline cerebral near-infrared spectroscopy values: a single-centre observational study"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-5498","authenticated-orcid":false,"given":"Jan-Oliver","family":"Friess","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern , Bern, Switzerland"},{"name":"Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School , Boston, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurus","family":"Beeler","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern , Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern , Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik P","family":"Guensch","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern , Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Levis","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern , Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern , Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Wollborn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansjoerg","family":"Jenni","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern , Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of 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