{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T10:11:35Z","timestamp":1774779095166,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p\/><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Our goal was to evaluate the risk-adjusted effects of operative and non-operative repair on long-term outcomes in patients with congenitally corrected transposition of the great arteries and left ventricular outflow tract obstruction (CCTGA\/LVOTO).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We retrospectively reviewed 391 patients with CCTGA\/LVOTO from 2001 to 2020 (operative group, 282; non-operative group, 109) in 3 centres in China. The operative group included 73 patients who underwent anatomical repair and 209 patients who underwent non-anatomical repair. The median follow-up time was 8.5\u2009years. The inverse probability of treatment weighted-adjusted Cox regression and a Kaplan\u2013Meier analysis were used to evaluate long-term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Operative repair did not reduce the hazard ratio (HR) of death, tricuspid regurgitation or New York Heart Association functional class III\/IV, but a significantly increased HR was observed for pulmonary valve regurgitation [HR, 2.84; 95% confidence interval (CI), 1.10\u20137.33; P\u2009=\u20090.031]. Compared with that in the non-operative group, anatomical repair resulted in significantly increased HRs for death (HR, 2.94; 95% CI, 1.10\u20137.87; P\u2009=\u20090.032) and pulmonary valve regurgitation (HR, 9.71; 95% CI, 3.66\u201325.77; P\u2009&amp;lt;\u20090.001). Subgroup analysis showed that in patients with CCTGA\/LVOTO with moderate or worse tricuspid regurgitation (\u2265 moderate), anatomical repair significantly reduced the HR of death. An inverse probability of treatment weighting-adjusted Kaplan\u2013Meier analysis showed that the survival rates at 5 and 10\u2009days postoperatively were 88.2\u2009\u00b1\u20094.0% and 79.0\u2009\u00b1\u20097.9%, respectively, in the anatomical repair group; these rates were significantly lower than the rates in the non-operative group (95.4\u2009\u00b1\u20092.0% and 91.8\u2009\u00b1\u20092.8%; P\u2009=\u20090.032).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>For patients with CCTGA\/LVOTO, operative repair does not provide superior long-term outcomes, and anatomical repair results in a higher incidence of death. However, in patients with CCTGA\/LVOTO with tricuspid regurgitation \u2265 moderate, anatomical repair can reduce the risk of death in the long term.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejcts\/ezad051","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:24:30Z","timestamp":1677504270000},"source":"Crossref","is-referenced-by-count":4,"title":["Can an operation provide superior outcomes for corrected transposition of the great arteries with left ventricular outflow tract obstruction? 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