{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:53:53Z","timestamp":1768348433753,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The goal of this study was to identify the clinical significance of the deoxyribonucleic acid (DNA) damage response marker, phosphorylated H2A histone variant X, on the bridge to recovery in low-weight paediatric patients with dilated cardiomyopathy (DCM) after having a Berlin Heart EXCOR implanted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Consecutive paediatric patients with DCM who had an EXCOR implanted for DCM at our hospital between 2013 and 2021 were reviewed. Patients were classified into 2 groups according to the degree of DNA damage in the left ventricular cardiomyocytes\u2014the low DNA damage group and the high DNA damage group\u2014using the median value as the threshold. We examined and compared the preoperative factors and histologic findings associated with cardiac functional recovery following the explant procedure in the 2 groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Competing outcome analysis of 18 patients (median body weight, 6.1\u2009kg) showed that the incidence of an EXCOR explant was 40% at 1\u2009year after the implant procedure. Serial echocardiography revealed significant left ventricular functional recovery in the low DNA damage group 3\u2009months after the implant. The univariable Cox proportional hazards model revealed that the percentage of phosphorylated H2A histone variant X-positive cardiomyocytes was the significant factor associated with cardiac recovery and the EXCOR explant (hazard ratio, 0.16; 95% confidence interval, 0.027\u20130.51; P\u2009=\u20090.0096).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The degree of DNA damage response to the EXCOR implant may aid in predicting the bridge to recovery with EXCOR among low-weight paediatric patients with DCM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad064","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T19:30:02Z","timestamp":1677007802000},"source":"Crossref","is-referenced-by-count":5,"title":["Cardiomyocyte deoxyribonucleic acid damage and cardiac recovery in paediatric dilated cardiomyopathy"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-4919","authenticated-orcid":false,"given":"Yuji","family":"Tominaga","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine , Osaka, Japan"},{"name":"Department of Pediatric Cardiovascular Surgery, National Cerebral and Cardiovascular Center , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-1069","authenticated-orcid":false,"given":"Takuji","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Kugo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moyu","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoto","family":"Sakaniwa","sequence":"additional","affiliation":[{"name":"Department of Public Health, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"2024012912074081600_ezad064-B1","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1161\/CIRCULATIONAHA.113.002767","article-title":"Long-term outcomes of DNA diagnosed during childhood: results from a national population-based study of childhood cardiomyopathy","volume":"128","author":"Alexander","year":"2013","journal-title":"Circulation"},{"key":"2024012912074081600_ezad064-B2","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/ehf2.13233","article-title":"Predicting outcome in children with dilated cardiomyopathy: the use of repeated measurements of risk factors for outcome","volume":"8","author":"van der Meulen","year":"2021","journal-title":"ESC Heart Fail"},{"key":"2024012912074081600_ezad064-B3","doi-asserted-by":"crossref","first-page":"e003450","DOI":"10.1161\/JAHA.116.003450","article-title":"Natural History of Dilated Cardiomyopathy in Children","volume":"5","author":"Puggia","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2024012912074081600_ezad064-B4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jchf.2014.07.011","article-title":"T. 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