{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:12:03Z","timestamp":1790802723446,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022438","name":"European Association for Cardio-Thoracic Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Early right-sided heart failure (RHF) was seen in 22% of recipients of a left ventricular assist device (LVAD) in the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). However, the optimal treatment of post-LVAD RHF is not well known. Levosimendan has proven to be effective in patients with cardiogenic shock and in those with end-stage heart failure. We sought to evaluate the efficacy of levosimendan on post-LVAD RHF and 30-day and 1-year mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The EUROMACS Registry was used to identify adults with mainstream continuous-flow LVAD implants who were treated with preoperative levosimendan compared to a propensity matched control cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In total, 3661 patients received mainstream LVAD, of which 399 (11%) were treated with levosimendan pre-LVAD. Patients given levosimendan had a higher EUROMACS RHF score [4 (2\u2013 5.5) vs 2 (2\u2013 4); P\u2009&amp;lt;\u20090.001], received more right ventricular assist devices (RVAD) [32 (8%) vs 178 (5.5%); P\u2009=\u20090.038] and stayed longer in the intensive care unit post-LVAD implant [19 (8\u201335) vs 11(5\u201325); P\u2009&amp;lt;\u20090.001]. Yet, there was no significant difference in the rate of RHF, 30-day, or 1-year mortality. Also, in the matched cohort (357 patients taking levosimendan compared to an average of 622 controls across 20 imputations), we found no evidence for a difference in postoperative severe RHF, RVAD implant rate, length of stay in the intensive care unit or 30-day and 1-year mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In this analysis of the EUROMACS registry, we found no evidence for an association between levosimendan and early RHF or death, albeit patients taking levosimendan had much higher risk profiles. For a definitive conclusion, a multicentre, randomized study is warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad095","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T16:03:41Z","timestamp":1678723421000},"source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of levosimendan infusion in patients undergoing a left ventricular assist device implant in a propensity score matched analysis of the EUROMACS registry\u2014the Euro LEVO-LVAD study"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-0019","authenticated-orcid":false,"given":"Mahmoud","family":"Abdelshafy","sequence":"first","affiliation":[{"name":"Discipline of Cardiology, Saolta Healthcare Group, Galway University Hospital, Health Service Executive , Galway, Ireland"},{"name":"CORRIB Core Lab, University of Galway , Galway, Ireland"},{"name":"Department of Cardiology, Al-Azhar University , Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus MC University Medical Center , Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Simpkin","sequence":"additional","affiliation":[{"name":"School of Mathematical and Statistical Sciences, University of Galway , Galway, Ireland"},{"name":"Insight Centre for Data Analytics, University of Galway , Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elkoumy","sequence":"additional","affiliation":[{"name":"Discipline of Cardiology, Saolta Healthcare Group, Galway University Hospital, Health Service Executive , Galway, Ireland"},{"name":"CORRIB Core Lab, University of Galway , Galway, Ireland"},{"name":"Islamic Center of Cardiology and Cardiac Surgery, Al-Azhar University , Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse R","family":"Kimman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus MC University Medical Center , Rotterdam, Netherlands"},{"name":"Department of Intensive Care, Erasmus MC University Medical Center , Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar","family":"Elsherbini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus MC University Medical Center , Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Elzomor","sequence":"additional","affiliation":[{"name":"Discipline of Cardiology, Saolta Healthcare Group, Galway University Hospital, Health Service Executive , Galway, Ireland"},{"name":"CORRIB Core Lab, University of Galway , Galway, Ireland"},{"name":"Islamic Center of Cardiology and Cardiac Surgery, Al-Azhar University , Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo M M H","family":"de By","sequence":"additional","affiliation":[{"name":"EACTS House , Windsor, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Gollmann-Tepek\u00f6yl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Innsbruck , Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berchtold-Herz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Medicine, Heart Center Freiburg University, University of Freiburg , Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-0477","authenticated-orcid":false,"given":"Antonio","family":"Loforte","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, S. Orsola University Hospital, ALMA Mater Studiorum University of Bologna, IRCCS Bologna , Bologna, Italy"},{"name":"Department of Surgical Sciences, University of Turin , Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3317-6219","authenticated-orcid":false,"given":"David","family":"Reineke","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital , Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-1295","authenticated-orcid":false,"given":"Felix","family":"Schoenrath","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin , Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) , Partner Site , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9095-1277","authenticated-orcid":false,"given":"Lech","family":"Paluszkiewicz","sequence":"additional","affiliation":[{"name":"Department for Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre NRW, Ruhr-University Bochum , Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6956-9110","authenticated-orcid":false,"given":"Jan","family":"Gummert","sequence":"additional","affiliation":[{"name":"Department for Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre NRW, Ruhr-University Bochum , Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-9287","authenticated-orcid":false,"given":"Paul","family":"Mohacsi","sequence":"additional","affiliation":[{"name":"HerzGef\u00e4ssZentrum im Park , Z\u00fcrich, 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