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However, we caution against the administration of Andexanet alfa prior to cardiopulmonary bypass as it can induce heparin resistance and complicate the perioperative monitoring of anticoagulation during cardiopulmonary bypass.<\/jats:p>","DOI":"10.1093\/ejcts\/ezad100","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T23:16:39Z","timestamp":1679440599000},"source":"Crossref","is-referenced-by-count":15,"title":["Andexanet alfa in acute aortic syndrome: first UK experience"],"prefix":"10.1093","volume":"63","author":[{"given":"Nawwar","family":"Al-Attar","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Golden Jubilee National Hospital , Clydebank, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed F","family":"Sedeek","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Golden Jubilee National Hospital , Clydebank, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"McCall","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Golden Jubilee National Hospital , Clydebank, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Travers","sequence":"additional","affiliation":[{"name":"Department of Haematology, Golden Jubilee National Hospital , Clydebank, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"2023061607224439000_ezad100-B1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nm.3102","article-title":"A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa","volume":"19","author":"Lu","year":"2013","journal-title":"Nat Med"},{"key":"2023061607224439000_ezad100-B2","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1182\/bloodadvances.2017007112","article-title":"Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa","volume":"1","author":"Siegal","year":"2017","journal-title":"Blood Adv"},{"key":"2023061607224439000_ezad100-B3","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJMoa1814051","article-title":"Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors","volume":"380","author":"Connolly","year":"2019","journal-title":"N Engl J Med"},{"key":"2023061607224439000_ezad100-B4","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1053\/j.jvca.2020.10.042","article-title":"Successful antithrombin administration in andexanet alfa-associated heparin resistance","volume":"35","author":"Apostel","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"2023061607224439000_ezad100-B5"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article-pdf\/doi\/10.1093\/ejcts\/ezad100\/49583909\/ezad100.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/63\/6\/ezad100\/50625483\/ezad100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/63\/6\/ezad100\/50625483\/ezad100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T07:22:57Z","timestamp":1686900177000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/doi\/10.1093\/ejcts\/ezad100\/7082536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,21]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezad100","relation":{},"ISSN":["1873-734X"],"issn-type":[{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6,1]]},"published":{"date-parts":[[2023,3,21]]},"article-number":"ezad100"}}