{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:13:57Z","timestamp":1786994037474,"version":"build-2736575974"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The prevalence and aetiology of acute aortic dissection type A (AADA) in patients \u226430\u2009years is unknown. The aims of this clinical study were to determine the prevalence and potential aetiology of AADA in surgically treated patients \u226430\u2009years and to evaluate the respective postoperative outcomes in this selective group of patients in a large multicentre study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Retrospective data collection was performed at 16 participating international aortic institutions. All patients \u226430 years at the time of dissection onset were included. The postoperative results were analysed with regard to connective tissue disease (CTD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The overall prevalence of AADA \u226430 years was 1.8% (139 out of 7914 patients), including 51 (36.7%) patients who were retrospectively diagnosed with CTD. Cumulative postoperative mortality was 8.6%, 2.2% and 1.4%. Actuarial survival was 80% at 10\u2009years postoperatively. Non-CTD patients (n\u2009=\u200988) had a significantly higher incidence of arterial hypertension (46.6% vs 9.8%; P\u2009&amp;lt;\u20090.001) while AADA affected the aortic root (P\u2009&amp;lt;\u20090.001) and arch (P\u2009=\u20090.029) significantly more often in the CTD group. A positive family history of aortic disease was present in 9.4% of the study cohort (n\u2009=\u200913).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The prevalence of AADA in surgically treated patients \u226430\u2009years is &amp;lt;2% with CTD and arterial hypertension as the 2 most prevalent triggers of AADA. Open surgery may be performed with good early results and excellent mid- to long-term outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad112","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T15:37:15Z","timestamp":1679585835000},"source":"Crossref","is-referenced-by-count":18,"title":["Acute type A aortic dissection in adolescents and young adults under 30 years of age: demographics, aetiology and postoperative outcomes of 139 cases"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-1764","authenticated-orcid":false,"given":"Maximilian","family":"Luehr","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart Center, University of Cologne , Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital 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