{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:03:29Z","timestamp":1768352609591,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Our goal was to evaluate the association between the distance of the tumour to the visceral pleura and the rate of local recurrence in patients surgically treated for stage pI lung cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We conducted a single-centre retrospective review of 578 consecutive patients with clinical stage IA lung cancer who underwent a lobectomy or segmentectomy from January 2010 to December 2019. We excluded 107 patients with positive margins, previous lung cancer, neoadjuvant treatment and pathological stage II or higher status or for whom preoperative computed tomography (CT) scans were not available at the time of the study. The distance between the tumour and the closest visceral pleura area (fissure\/mediastinum\/lateral) was assessed by 2 independent investigators who used preoperative CT scans and multiplanar 3-dimensional reconstructions. An area under the receiver operating characteristic curve analysis was performed to determine the best threshold for the tumour\/pleura distance. Then multivariable survival analyses were used to assess the relationship between local recurrence and this threshold in relation to other variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Local recurrence occurred in 27\/471 patients (5.8%). A cut-off value of 5\u2009mm between the tumour and the pleura was determined statistically. In the multivariable analysis, the local recurrence rate was significantly higher in patients with a tumour-to-pleura distance \u22645 mm compared to patients with a tumour-to-pleura distance &amp;gt;5 mm (8.5% vs 2.7%, hazard ratio 3.36, 95% confidence interval: 1.31\u20138.59, P\u2009=\u20090.012). Subgroup analyses of patients with pIA and tumour size \u22642 cm identified local recurrences in 4\/78 patients treated with segmentectomy (5.1%), with a significantly higher occurrence with tumour-to-pleura distances \u22645 mm (11.4% vs 0%, P\u2009=\u20090.037), and in 16\/292 patients treated with lobectomy (5.5%) without significant higher occurrence in tumour-to-pleura distances of \u22645 mm (7.7% vs 3.4%, P\u2009=\u20090.13).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The peripheral location of a lung tumour is associated with a higher rate of local recurrence and should be taken into account during preoperative planning when considering segmental versus lobar resection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad130","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T14:52:17Z","timestamp":1680533537000},"source":"Crossref","is-referenced-by-count":4,"title":["Peripheral location of lung cancer is associated with higher local disease recurrence"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-3899","authenticated-orcid":false,"given":"Alex","family":"Fourdrain","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery\u2014H\u00f4pital Nord\u2014APHM\u2014Aix-Marseille University , Marseille, France"},{"name":"Research Unit SSPC (Simplification des Soins des Patients chirurgicaux Complexes), Amiens University Hospital , Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassili","family":"Anastay","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\u2014H\u00f4pital Nord\u2014APHM\u2014Aix-Marseille University , Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Pauly","sequence":"additional","affiliation":[{"name":"CEReSS-Health Service Research and Quality of Life Center, (EA, 3279, ) - Aix-Marseille University\u2014Marseille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Braggio","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\u2014H\u00f4pital Nord\u2014APHM\u2014Aix-Marseille University , Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier-Benoit","family":"D'Journo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\u2014H\u00f4pital Nord\u2014APHM\u2014Aix-Marseille University , Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Boulate","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\u2014H\u00f4pital Nord\u2014APHM\u2014Aix-Marseille University , Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3305-6989","authenticated-orcid":false,"given":"Pascal-Alexandre","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery\u2014H\u00f4pital Nord\u2014APHM\u2014Aix-Marseille University , Marseille, France"},{"name":"Predictive Oncology Laboratory, CRCM, Inserm, UMR 1068, CNRS, UMR 7258, Aix-Marseille University UM105 , Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"issue":"Suppl 2","key":"2023042603534007900_ezad130-B1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/resp.13920","article-title":"Video-assisted thoracoscopic surgery as the gold standard for lung cancer surgery","volume":"25","author":"Sihoe","year":"2020","journal-title":"Respirology"},{"key":"2023042603534007900_ezad130-B2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/JTO.0b013e31824cbad8","article-title":"Predictors of death, local recurrence, and distant metastasis in completely resected pathological stage-I non-small-cell lung cancer","volume":"7","author":"Hung","year":"2012","journal-title":"J Thorac Oncol"},{"key":"2023042603534007900_ezad130-B3","doi-asserted-by":"crossref","first-page":"e574","DOI":"10.1016\/j.cllc.2020.10.009","article-title":"Nomograms for Predicting Overall and Recurrence-free Survival From Pathologic Stage IA and IB Lung Cancer After Lobectomy","volume":"22","author":"Merritt","year":"2021","journal-title":"Clin Lung Cancer"},{"key":"2023042603534007900_ezad130-B4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/SLA.0000000000001708","article-title":"Long-term survival based on the surgical approach to lobectomy for clinical stage I nonsmall cell lung cancer: comparison of robotic, video-assisted thoracic surgery, and thoracotomy lobectomy","volume":"265","author":"Yang","year":"2017","journal-title":"Ann Surg"},{"key":"2023042603534007900_ezad130-B5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chest.2016.10.010","article-title":"The 8th Edition Lung Cancer. 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