{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:39:45Z","timestamp":1793813985261,"version":"4.6.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to examine whether perioperative changes in cerebral blood flow (CBF) relate to postoperative neurological deficits in patients undergoing aortic arch surgery involving antegrade selective cerebral perfusion (ASCP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We retrospectively analysed data from patients who underwent aortic arch surgery involving ASCP and perioperative transcranial Doppler assessments. Linear mixed-model analyses were performed to examine perioperative changes in mean bilateral blood velocity in the middle cerebral arteries, reflecting changes in CBF, and their relation with neurological deficits, i.e. ischaemic stroke and\/or delirium. Logistic regression analyses were performed to explore possible risk factors for postoperative neurological deficits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In our study population (N\u2009=\u2009102), intraoperative blood velocities were lower compared to preoperative levels, and lowest during ASCP. Thirty-six (35%) patients with postoperative neurological deficits (ischaemic stroke, n\u2009=\u20099; delirium, n\u2009=\u200925; both, n\u2009=\u20092) had lower blood velocity during ASCP compared to patients without (25.4 vs 37.0\u2009cm\/s; P\u2009=\u20090.002). Logistic regression analyses revealed lower blood velocity during ASCP as an independent risk factor for postoperative neurological deficits (odds ratio\u2009=\u20090.959; 95% confidence interval: 0.923, 0.997; P\u2009=\u20090.037).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Lower intraoperative CBF during ASCP seems independently related to postoperative neurological deficits in patients undergoing aortic arch surgery. Because CBF is a modifiable factor during ASCP, our observation has significant potential to improve clinical management and prevent neurological deficits.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad144","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T15:41:02Z","timestamp":1681400462000},"source":"Crossref","is-referenced-by-count":12,"title":["Perioperative cerebral perfusion in aortic arch surgery: a potential link with neurological outcome"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-7345","authenticated-orcid":false,"given":"Ralf W J","family":"Weijs","sequence":"first","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center , Nijmegen, Netherlands"},{"name":"Department of Cardiothoracic Surgery, St. Antonius Hospital , Nieuwegein, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma C","family":"Tromp","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, St. Antonius Hospital , Nieuwegein, Netherlands"},{"name":"Department of Neurology, Leiden University Medical Center , Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin H","family":"Heijmen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St. Antonius Hospital , Nieuwegein, Netherlands"},{"name":"Department of Cardiothoracic Surgery, Radboud University Medical Center , Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje A","family":"Seeber","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology, St. Antonius Hospital , Nieuwegein, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J C W","family":"van Belle-van Haaren","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic 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