{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:44:55Z","timestamp":1792154695480,"version":"4.4.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Foundation for Research and Promotion of Endoscopy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Polyglycolic acid (PGA) sheets are difficult to adapt to the central airway because of poor durability against high air pressure. Therefore, we developed a novel layered PGA material to cover the central airway and examined its morphologic traits and functional performance as a potential tracheal replacement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A critical-size defect in rat cervical tracheas was covered with the material. Morphologic changes were bronchoscopically and pathologically evaluated. Functional performance was evaluated by regenerated ciliary area, ciliary beat frequency and ciliary transport function determined by measuring the moving distance of microspheres dropped onto the trachea (\u00b5m\/s). The evaluation time points were 2\u2009weeks, 1\u2009month, 2\u2009months and 6\u2009months after surgery (n\u2009=\u20095, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Forty rats underwent implantation, and all survived. Histological examination confirmed ciliated epithelization on the luminal surface after 2\u2009weeks. Neovascularization was observed after 1\u2009month, tracheal glands after 2\u2009months and chondrocyte regeneration after 6\u2009months. Although the material was gradually replaced by self-organization, tracheomalacia was not bronchoscopically observed at any time point. The area of regenerated cilia significantly increased between 2\u2009weeks and 1\u2009month (12.0% vs 30.0%; P\u2009=\u20090.0216). The median ciliary beat frequency significantly improved between 2\u2009weeks and 6\u2009months (7.12 vs 10.04\u2009Hz; P\u2009=\u20090.0122). The median ciliary transport function was significantly improved between 2\u2009weeks and 2\u2009months (5.16 vs 13.49\u2009\u00b5m\/s; P\u2009=\u20090.0216).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The novel PGA material showed excellent biocompatibility and tracheal regeneration both morphologically and functionally 6\u2009months after tracheal implantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad159","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T16:57:41Z","timestamp":1682441861000},"source":"Crossref","is-referenced-by-count":6,"title":["Development of novel layered polyglycolic acid sheet for regeneration of critical-size defect in rat trachea"],"prefix":"10.1093","volume":"63","author":[{"given":"Yoshitake","family":"Murata","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Kyoto 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