{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:51:28Z","timestamp":1780602688646,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T00:00:00Z","timestamp":1682121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Jiangsu Key Research and Development Plan","award":["BE2020653"],"award-info":[{"award-number":["BE2020653"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>To determine the impact of recurrent laryngeal nerve (RLN) lymph node (LN) dissection on survival and postoperative complications in patients with oesophageal squamous cell carcinoma (ESCC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Patients with cT1-4N0-3M0 thoracic ESCC who underwent oesophagectomy and two-field lymphadenectomy from three institutions were included. The entire cohort was divided into three groups that underwent the total two-field lymphadenectomy (T-2FL), standard two-field lymphadenectomy (S-2FL) or unilateral RLN-LN dissection plus S-2FL (U-2FL) based on the extent of RLN-LN dissection. Subgroup analyses were also performed and were stratified by treatment modality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Both the U-2FL and T-2FL groups had significantly superior outcomes compared with the S-2FL group (overall survival: U-2FL versus S-2FL: P\u2009=\u20090.002; T-2FL versus S-2FL: P\u2009&amp;lt;\u20090.001; recurrence-free survival: U-2FL versus S-2FL: P\u2009=\u20090.01; T-2FL versus S-2FL: P\u2009&amp;lt;\u20090.001). Moreover, no significant differences were observed between U-2FL and T-2FL regarding overall survival (P\u2009&amp;gt;\u20090.05) and recurrence-free survival (P\u2009&amp;gt;\u20090.05), irrespective of administration of neoadjuvant therapy plus oesophagectomy or upfront oesophagectomy. Additionally, the extent of RLN-LN dissection was not an independent predictor of stage migration (P\u2009=\u20090.14) but was for postoperative nodal upstaging (P\u2009=\u20090.02). Notably, S-2FL brought significantly lowered risk in postoperative complications, especially for RLN palsy, when compared with T-2FL (P\u2009=\u20090.002) but not U-2FL (P\u2009=\u20090.72).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Adequacy of RLN-LN dissection is an important prognosticator for improved overall survival and recurrence-free survival in patients with thoracic ESCC. U-2FL may serve as an alternative to T-2FL in selected populations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad168","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T17:38:56Z","timestamp":1682185136000},"source":"Crossref","is-referenced-by-count":5,"title":["Impact of the extent of recurrent laryngeal nerve lymphadenectomy on thoracic esophageal squamous cell carcinoma: a real-world multicentre study"],"prefix":"10.1093","volume":"63","author":[{"given":"Sukai","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University , Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Section of Esophageal Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peidong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University , Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University , Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University , Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University , Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Section of Esophageal Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7595-092X","authenticated-orcid":false,"given":"Yongbing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University , Suzhou, 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